Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study

Autor:	Lishanthe Gunarathne, Nishantha Nanayakkara, Yomani D. Sarathkumara, Yoshimi Tsuda, Kenta Shimizu, Kumiko Yoshimatsu, Devinda S. Muthusinghe, Sithumini M. W. Lokupathirage, Jiro Arikawa, Chandika D. Gamage
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine medicine.medical_specialty Cross-sectional study lcsh:QR1-502 Logistic regression lcsh:Microbiology Article 03 medical and health sciences 0302 clinical medicine tropical nephropathy Virology Internal medicine parasitic diseases medicine 030212 general & internal medicine Thailand orthohantavirus Risk factor Hantavirus business.industry Public health rodent social sciences medicine.disease 030104 developmental biology Infectious Diseases Etiology Hantavirus Infection business geographic locations Kidney disease
Zdroj:	Viruses Volume 11 Issue 8 Viruses, Vol 11, Iss 8, p 700 (2019)
ISSN:	1999-4915
Popis:	Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unmatched case-control comparison in two geographically distinct areas of Sri Lanka, Girandurukotte (CKDu endemic) and Kandy (CKDu non-endemic) to determine whether exposure to hantaviruses is a potential risk factor in patients with kidney disease. An indirect immunofluorescent antibody assay using two antigens, Thailand orthohantavirus-infected and recombinant N protein-expressing Vero E6 cells, were used for serodiagnosis. Participants&rsquo demographic and other socio-economic data were collected through a structured questionnaire. Fifty kidney disease patients and 270 controls from Kandy and 104 kidney disease patients and 242 controls from Girandurukotte were examined. Seropositivities were 50% and 17.4% in kidney patients and controls, respectively, in Girandurukotte, and they were 18% and 7% in Kandy. The odds of exposure to hantaviruses were higher for kidney disease patients than for controls in both Girandurukotte (OR:3.66, 95% CI:2.01 to 6.64) and Kandy (OR:2.64, 95% CI:1.07 to 6.54) in binary logistic regression models. According to statistical analysis, individuals exposed to hantaviruses had a higher risk of developing renal impairment. Therefore, hantavirus infection might be an important risk factor for development of kidney disease in Sri Lanka.
Databáze:	OpenAIRE
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