Heterogeneity in the responsiveness to long-term lifestyle intervention and predictability in obese women with polycystic ovary syndrome
| Autor: | Renato Pasquali, Graciela Estela Cognigni, Alessandra Gambineri, W. Ciampaglia, Carla Cavazza, Uberto Pagotto, Daniela Ibarra Gasparini |
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| Přispěvatelé: | Pasquali R., Gambineri A., Cavazza C., Ibarra Gasparini D., Ciampaglia W., Cognigni G.E., Pagotto U. |
| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Waist BODY-FAT DISTRIBUTION INSULIN-RESISTANCE WEIGHT-LOSS LUTEINIZING-HORMONE ANDROGEN EXCESS SENSITIVITY MECHANISM METFORMIN PROFILES FEATURES Endocrinology Diabetes and Metabolism Intra-Abdominal Fat Overweight Endocrinology Waist–hip ratio Insulin resistance Predictive Value of Tests Weight loss Internal medicine Weight Loss medicine Humans Obesity Aged business.industry Hyperandrogenism Androstenedione General Medicine Middle Aged medicine.disease Polycystic ovary Logistic Models Female Insulin Resistance medicine.symptom business Risk Reduction Behavior Follow-Up Studies Polycystic Ovary Syndrome |
| Zdroj: | European Journal of Endocrinology. 164:53-60 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje-10-0692 |
| Popis: | BackgroundTreatment of obesity improves all features of the polycystic ovary syndrome (PCOS). There is, however, a heterogeneous response to weight loss, and predictive factors are unknown.ObjectiveThis follow-up study aimed to investigate obese women with PCOS treated with a long-term lifestyle program to evaluate responsiveness and predictability.MethodsOne hundred PCOS women meeting the criteria for selection were invited to participate and 65 of them agreed. Lifestyle intervention had consisted of a 1200–1400 kcal/day diet for 6 months, followed by mild calorie restriction and physical activity. The protocol, which was similar at baseline and follow-up, included anthropometry, clinical evaluation, pelvic ultrasound, and laboratory investigations. The mean follow-up period was 20.4±12.5 months.ResultsAfter the follow-up period, women were reclassified into three groups according to the persistence (group 1, 15.4%), partial (group 2, 47.7%), or complete (group 3, 36.9%) disappearance of the categorical features of PCOS (hyperandrogenism, menses, and ovulatory dysfunctions). Duration of the follow-up and extent of weight loss were similar among the three groups, as were fasting and glucose-stimulated insulin and indices of insulin resistance. Baseline waist circumference, waist to hip ratio (WHR), and androstenedione blood levels were negatively correlated with a better outcome in the univariate analysis. However, only basal androstenedione values persisted to a highly significant extent (PConclusionsResponsiveness to weight loss in overweight/obese PCOS women varies considerably and more than one third of women may achieve full recovery. These findings add new perspectives to the impact of obesity on the pathophysiology of PCOS. |
| Databáze: | OpenAIRE |
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