Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain
| Autor: | Shaoyu Ge, Adrian Di Antonio, Chih Hao Yang, P. Varma, Jenny Hsieh, Gregory W. Kirschen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Neurite Neurogenesis Gating Hippocampal formation Biology Hippocampus General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Mice 0302 clinical medicine Biological neural network Animals RNA-Seq lcsh:QH301-705.5 Sphingosine-1-Phosphate Receptors G protein-coupled receptor Neurons Environmental enrichment Sphingolipids Dentate gyrus Gene expression profiling Mice Inbred C57BL 030104 developmental biology lcsh:Biology (General) Gene Knockdown Techniques Dentate Gyrus Lipidomics Female Neuroscience 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Cell Reports, Vol 30, Iss 4, Pp 959-968.e3 (2020) |
| Popis: | Summary: In the adult brain, new dentate granule cells integrate into neural circuits and participate in hippocampal functioning. However, when and how they initiate this integration remain poorly understood. Using retroviral and live-imaging methods, we find that new neurons undergo neurite remodeling for competitive horizontal-to-radial repositioning in the dentate gyrus prior to circuit integration. Gene expression profiling, lipidomics analysis, and molecular interrogation of new neurons during this period reveal a rapid activation of sphingolipid signaling mediated by sphingosine-1-phosphate receptor 1. Genetic manipulation of this G protein-coupled receptor reveals its requirement for successful repositioning of new neurons. This receptor is also activated by hippocampus-engaged behaviors, which enhances repositioning efficiency. These findings reveal that activity-dependent sphingolipid signaling regulates cellular repositioning of new dentate granule cells. The competitive horizontal-to-radial repositioning of new neurons may provide a gating strategy in the adult brain to limit the integration of new neurons into pre-existing circuits. : Yang et al. show that prior to circuit integration, adult-born dentate granule cells undergo horizontal-to-radial transitioning, which is regulated by sphingolipid signaling via sphingosine-1-phosphate receptor 1. Keywords: G protein-coupled receptor, electrophysiological maturation, dentate granule cell, environmental enrichment, lipidomics, adult hippocampal neurogenesis, circuit integration initiation, sphingosine-1-phosphate receptor 1, hippocampus behavior-engaged activation |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|