Anti-phospholipid antibody prevalence and association with subclinical atherosclerosis and atherothrombosis in the general population
| Autor: | Carlo Selmi, Simone Aldo Lari, Carlo Alberto Scirè, P. Zermiani, Torsten Matthias, Natasa Isailovic, Sandra Neidhöfer, Pier Maria Battezzati, Damiano Baldassarre, Elena Generali, Massimo Zuin, Maria De Santis, Angela Ceribelli |
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| Přispěvatelé: | Selmi, C, De Santis, M, Battezzati, P, Generali, E, Lari, S, Ceribelli, A, Isailovic, N, Zermiani, P, Neidhofer, S, Matthias, T, Scire, C, Baldassarre, D, Zuin, M |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Heart Diseases Epidemiology Population Cardiovascular event Serum biomarker 030204 cardiovascular system & hematology Random Allocation Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Prevalence Humans Medicine 030212 general & internal medicine Myocardial infarction education Stroke Aged education.field_of_study Framingham Risk Score business.industry Thrombosis Odds ratio Middle Aged Atherosclerosis medicine.disease Cross-Sectional Studies Italy Intima-media thickness Population Surveillance Antibodies Antiphospholipid Female Cardiology and Cardiovascular Medicine business Antiphospholipid antibodie Body mass index Biomarkers |
| Zdroj: | International Journal of Cardiology. 300:209-213 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2019.10.042 |
| Popis: | Background There is no agreement on the prevalence of anti-phospholipid antibodies (aPLs) and the correlation with atherosclerosis and cardiovascular (CV) events in the general population. Methods We performed a cross-sectional study on 1712 randomly enrolled subjects from a Northern Italian city to investigate the presence of aPLs and the association with subclinical atherosclerosis (using the carotid artery intima media thickness measured as inter-adventitia common carotid artery diameters - ICCAD) and retrospectively collected CV factors and events (i.e. acute myocardial infarction, stroke, and peripheral obliterans arterial vasculopathy) using physician-assisted questionnaires. We tested serum IgG, IgM, and IgA anti-cardiolipin, anti-beta2glycoprotein I (aGPI), and anti-phosphatidylserine-prothrombin antibodies. Results Positive aPLs were found in 15.1% of the subjects, with no differences between sex but with higher rates in older subjects. Carotid subclinical atherosclerosis was more frequent in aPL positive subjects; more specifically, aGPI IgA were associated with higher ICCAD average (adjusted beta 0.51, 95% confidence interval (CI)0.17–0.84; p = 0.003). A positive history of CV events was also more frequent in aPL positive subjects (odds ratio (OR) 1.67, 95%CI 1.08–2.54; p = 0.012), particularly peripheral obliterans arterial vasculopathy ( OR 2.02 ; 95%CI 1.14–3.57; p = 0.015). Among subjects with a Framingham risk score >20, and/or diabetes, and/or body mass index >3 5 kg/m 2 , aPL positivity was associated to the highest risk of CV events (OR 2.52, 95%CI 1.24–5.11; p = 0.011). Conclusions APL prevalence in the general population is higher than previously reported. CV events and subclinical atherosclerosis are more frequent in the presence of aPL, particularly when a high CV risk coexists. |
| Databáze: | OpenAIRE |
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