Metabolism of Testosterone-4-14C by Rat Skin: Variations During the Hair Cycle
| Autor: | Walter Voigt, Barry P. Davis, G. Moretti, S.L. Hsia, E. Rampini |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Chromatography Paper Dehydrogenase Epiandrosterone Biology Androsterone chemistry.chemical_compound Endocrinology Biological Clocks Hair cycle Internal medicine medicine Animals Glabrous skin Testosterone Aldosterone Skin Carbon Isotopes integumentary system Hairy skin Hydroxysteroid Dehydrogenases Alopecia DNA Metabolism Rats chemistry Spectrophotometry Hair |
| Zdroj: | Endocrinology. 89:1506-1514 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-89-6-1506 |
| Popis: | The metabolism of testosterone-4-14C by the skin of Wistar rats was followed in three consecutive hair cycles. The major metabolites were Δ4-androstenedione and 5α-dihydrotestosterone; minor products were 5α-androstanedione, 3α-androstanediol, androsterone, epiandrosterone, and 3β-androstanediol. It was observed that the metabolism of testosterone fluctuated during the hair cycles in the hairy skin, but was without significant variations in glabrous skin. The 5α-reductase activity was examined by summing the 14C in the 5α-metabolites. When this activity was expressed in mg of DNA content of skin, an increase was observed in the resting phase of the hair cycle (telogen). The 17β-hydroxysteroid dehydrogenase activity was examined by summing the 14C in the 17-ketometabolites, and the maximal activity was found in the middle of the growing phase (anagen). (Endocrinology 89: 1506, 1971) |
| Databáze: | OpenAIRE |
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