Feasibility of Topical Applications of Natural High-Concentration Capsaicinoid Solutions in Patients with Peripheral Neuropathic Pain: A Retrospective Analysis
| Autor: | André Mouraux, Marjolein Leerink, Fanny Bauchy, Arnaud Steyaert, Antonio Ulpiano Trillig, Patrice Forget, Quetin-Leclercq Joëlle, Bernard le Polain de Waroux, Ronald Deumens |
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| Přispěvatelé: | Supporting clinical sciences, UCL - (SLuc) Service d'anesthésiologie, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Article Subject Erythema Administration Topical Drug Compounding Analgesic TRPV1 Capsaicinoid natural high-concentration Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans topical applications 030212 general & internal medicine Adverse effect Aged Pain Measurement Retrospective Studies Burning Pain lcsh:R5-920 capsaicinoid solutions business.industry Feasibility Antipruritics Middle Aged Pharmaceutical Solutions Anesthesiology and Pain Medicine Neurology chemistry Capsaicin Anesthesia Neuropathic pain Clinical Study Feasibility Studies Neuralgia Female medicine.symptom lcsh:Medicine (General) business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Pain Research & Management Pain Research and Management, Vol 2016 (2016) Pain Research & Management, Vol. 2016, no. 2016, p. 9703036 [1-6] (2016) |
| ISSN: | 1918-1523 1203-6765 |
| Popis: | Background.Capsaicin, one of several capsaicinoid compounds, is a potent TRPV1 agonist. Topical application at high concentration (high concentration, >1%) induces a reversible disappearance of epidermal free nerve endings and is used to treat peripheral neuropathic pain (PNP). While the benefit of low-concentration capsaicin remains controversial, the 8%-capsaicin patch (Qutenza®, 2010, Astellas, Netherlands) has shown its effectiveness. This patch is, however, costly and natural high-concentration capsaicinoid solutions may represent a cheaper alternative to pure capsaicin.Methods.In this retrospective study, 149 patients were screened, 132 were included with a diagnosis of neuropathic pain, and eighty-four were retained in the final analyses (median age: 57.5 years [IQR25–75: 44.7–67.1], male/female: 30/54) with PNP who were treated with topical applications of natural high-concentration capsaicinoid solutions (total number of applications: 137). Indications were postsurgical PNP (85.7%) and nonsurgical PNP (14.3%) (posttraumatic, HIV-related, postherpetic, and radicular PNP).Objectives.To assess the feasibility of topical applications of natural high-concentration capsaicinoid solutions for the treatment of PNP.Results.The median treated area was 250 cm2[IQR25–75: 144–531]. The median amount of capsaicinoids was 55.1 mg [IQR25–75: 28.7–76.5] per plaster and the median concentration was 172.3 μg/cm2[IQR25–75: 127.6–255.2]. Most patients had local adverse effects on the day of treatment, such as mild to moderate burning pain and erythema. 13.6–19.4% of the patients experienced severe pain or erythema. Following treatment, 62.5% of patients reported a lower pain intensity or a smaller pain surface, and 35% reported a sustained pain relief lasting for at least 4 weeks.Conclusion.Analgesic topical treatment with natural high-concentration capsaicinoid is feasible and may represent a low cost alternative to alleviate PNP in clinical practice. |
| Databáze: | OpenAIRE |
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