Positive selectable markers for use with mammalian cells in culture

Autor:	Martin A. Eglitis
Rok vydání:	1991
Předmět:	Genetics Genetic Markers Mammals Positive selection Drug Resistance Biology Transfection Culture Media Enzymes Transformation Genetic Genes Gene expression Molecular Medicine Animals Humans Selection Genetic Genetic Engineering Molecular Biology Selectable marker Cells Cultured
Zdroj:	Human gene therapy. 2(3)
ISSN:	1043-0342
Popis:	As more complicated gene expression studies are necessary, the need for multiple positive selection schemes becomes critical. Numerous selectable markers have been described over the last 25 years. A hallmark of the most generally useful markers is easy selection in a wide number of cell types. This paper briefly reviews the spectrum of available selectable markers and describes some of the applications that have been found for these genes, particularly with respect to retrovirus-mediated gene transfer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b17463e07da22c323363f64cd4b9d01 https://pubmed.ncbi.nlm.nih.gov/1751589 Zobrazit plný text záznamu