| Autor: |
Yu-lu Liu, Xiao-xia Zhu, Li-yun Niu, Ya Gao, Hui GAN, Zhuo-na Wu, Jian LI, Su-xiang Feng, Gui-fang Dou, Ruo-lan Gu, Zhi-yun Meng |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of pharmaceutical sciences. |
| ISSN: |
1520-6017 |
| Popis: |
GEN-0828, a proposed clinical candidate for hemophilia and trauma hemorrhage treatment, is a novel recombinant activated human factor VII (rFVIIa). The purpose of this paper is to compare the pharmacokinetics and pharmacodynamics of GEN-0828 in hemophilia B mice with those of NovoSeven®, the only marketed rFVIIa product worldwide., GEN-0828 and NovoSeven® showed similar affinity bioactivity to recombinant tissue factor (rTF) in vitro. Pharmacodynamics data indicated a generally similar hemostatic efficacy (ED |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
