Ipsilateral motor responses to focal transcranial magnetic stimulation in healthy subjects and acute-stroke patients
| Autor: | Victor De Pasqua, Giovanna Alagona, Valérie Delvaux, Giovanni Pennisi, Pascale Gerard, Alain Maertens De Noordhout, Francesco Nicoletti, Paul J. Delwaide |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Pyramidal Tracts Electromyography Biceps Severity of Illness Index Functional Laterality Central nervous system disease Physical medicine and rehabilitation Hand strength Reaction Time Medicine Humans Muscle Skeletal Stroke Motor skill Aged Advanced and Specialized Nursing Aged 80 and over Cerebral Cortex Neuronal Plasticity medicine.diagnostic_test Hand Strength business.industry Stroke Rehabilitation Recovery of Function Middle Aged medicine.disease Evoked Potentials Motor Transcranial Magnetic Stimulation Electric Stimulation Surgery Transcranial magnetic stimulation medicine.anatomical_structure Motor Skills Female Neurology (clinical) Cardiology and Cardiovascular Medicine business Motor cortex |
| Zdroj: | Stroke. 32(6) |
| ISSN: | 1524-4628 |
| Popis: | Background and Purpose —Prevalence and characteristics of ipsilateral upper limb motor-evoked potentials (MEPs) elicited by focal transcranial magnetic stimulation (TMS) were compared in healthy subjects and patients with acute stroke. Methods —Sixteen healthy subjects and 25 patients with acute stroke underwent focal TMS at maximum stimulator output over motor and premotor cortices. If present, MEPs evoked in muscles ipsilateral to TMS were analyzed for latency, amplitude, shape, and center of gravity (ie, preferential coil location to elicit them). In stroke patients, possible relationships between early ipsilateral responses and functional outcome at 6 months were sought. Results —With relaxed or slightly contracting target muscle, maximal TMS over the motor cortex failed to elicit ipsilateral MEPs in the first dorsal interosseous (FDI) or biceps of any of 16 normal subjects. In 5 of 8 healthy subjects tested, ipsilateral MEPs with latencies longer than contralateral MEPs were evoked in FDI muscle (in biceps, 6 of 8 subjects) during strong (>50% maximum) contraction of the target muscle. In 15 of 25 stroke patients, ipsilateral MEPs in the unaffected relaxed FDI (in biceps, 6 of 25 stroke patients) were evoked by stimulation of premotor areas of the affected hemisphere. Their latencies were shorter than those that MEPs evoked in the same muscle by stimulation of the motor cortex of the contralateral unaffected hemisphere. Such responses were never obtained in normal subjects and were mostly observed in patients with subcortical infarcts. Patients harboring these responses had slightly better bimanual dexterity after 6 months. Conclusions —Ipsilateral MEPs obtained in healthy individuals and stroke patients have different characteristics and probably different origins. In the former, they are probably conveyed via corticoreticulospinal or corticopropriospinal pathways, whereas in the latter, early ipsilateral MEPs could originate in hyperexcitable premotor areas. |
| Databáze: | OpenAIRE |
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