Overexpression and Clinicopathological Significance of Homeobox Gene Quox-1 in Oral Squamous Cell Carcinoma
| Autor: | Xing Long, Jian Li, Zhong-Chun Liu, Wenxin Li, Fan Zhu |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Epithelial dysplasia
Pathology medicine.medical_specialty Statistics as Topic Immunocytochemistry Nerve Tissue Proteins Biochemistry Western blot Humans Medicine Northern blot Molecular Biology Retrospective Studies Homeodomain Proteins Messenger RNA medicine.diagnostic_test business.industry Genes Homeobox Mouth Mucosa Cancer General Medicine medicine.disease Molecular biology Epithelium Gene Expression Regulation Neoplastic stomatognathic diseases medicine.anatomical_structure Carcinoma Squamous Cell Homeobox Mouth Neoplasms business Precancerous Conditions |
| Zdroj: | BMB Reports. 37:671-675 |
| ISSN: | 1976-6696 |
| DOI: | 10.5483/bmbrep.2004.37.6.671 |
| Popis: | The expression and clinicopathological significance of Quox-1 gene was studied in oral squamous cell carcinoma (OSCC). Immunocytochemistry and western blot analysis were used to examine the different expressions of Quox-1 protein in 114 OSCC specimens, 34 oral epithelial dysplasia specimens, and 16 normal oral mucosa specimens. RT-PCR and virtual Northern Blot were also used to examine the expression of Quox-1 mRNA. It was found that Quox-1 was not expressed in normal epithelium. However, as dysplastic lesions progressed Quox-1 expression increased (p0.01), and Quox-1 expression was not significantly different between severe dysplasia and highly differentiated OSCCs (p0.05). As the degree of differentiation decreased, Quox-1 positivity increased in OSCC (p0.01), and the rate of Quox-1 (81.58%) positivity in OSCC was higher than that in normal oral mucosa (p0.01). Our findings imply that the positive expression of Quox-1 is correlated with the histological classification of OSCCs. Thus, the expression of Quox-1 in OSCC may serve as a significant predicting factor of proliferative status and malignant degree, and it may also be a biological detection marker of oral mucosas initial cancer and of OSCC. |
| Databáze: | OpenAIRE |
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