Correction of hypocalcaemia in the critically ill: What is the haemodynamic benefit?
| Autor: | Stanislaw Jankowski, Philippe Bredas, Jean Louis Vincent, Robert J. Kahn |
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| Rok vydání: | 1995 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Time Factors endocrine system diseases Critical Illness Cardiac index Critical Care and Intensive Care Medicine Calcium Chloride Intensive care Anesthesiology Prevalence medicine Humans Hypocalcaemia Prospective Studies Infusions Intravenous Prospective cohort study Intensive care medicine Aged Hypocalcemia business.industry Metabolic disorder Hemodynamics nutritional and metabolic diseases Middle Aged medicine.disease Clinical trial Blood pressure Calcium business |
| Zdroj: | Intensive Care Medicine. 21:838-841 |
| ISSN: | 1432-1238 0342-4642 |
| DOI: | 10.1007/bf01700968 |
| Popis: | The prevalence of hypocalcaemia is known to be elevated in critically ill patients, but the expected benefit from calcium repletion in hypocalcaemic patients has not been well defined. The objective of the present study was therefore prospective determination of the cardiovascular response to calcium administration in critically ill patients with hypocalcaemia.A total of 17 patients found to have ionized hypocalcaemia (Ca2+1.05 mmol/l) from a group of 32 patients who were invasively monitored as part of their ICU management.Slow intravenous injection of 1 g of calcium chloride.Calcium administration was followed by an increase in mean arterial pressure from 77 +/- 8 to 90 +/- 12 mmHg (P0.01). There was no significant change in cardiac filling pressures or heart rate. Cardiac index and systemic vascular resistance increased slightly but not significantly (from 2.67 +/- 0.92 to 2.81 +/- 1.25 1/min.m2 and from 2133 +/- 647 to 2378 +/- 817 dynes.s.cm-5 m-2, respectively). Left ventricular stroke work index increased from 23 +/- 8 to 32 +/- 13 g.m/m2 (P0.01). These changes were maintained for 60 min.The correction of hypocalcaemia can result in a significant increase in arterial pressure that can persist for at least 1 h. Despite an associated improvement in left ventricular function, cardiac index and oxygen delivery do not increase significantly. |
| Databáze: | OpenAIRE |
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