Side effects of angiotensin converting enzyme inhibitor (captopril) in newborns and young infants
| Autor: | Urs Bauersfeld, Oskar Baenziger, Thomas J. Neuhaus, Bernhard Frey, Monika Herbst Gantenbein, Felix H. Sennhauser, Vera Bernet |
|---|---|
| Přispěvatelé: | University of Zurich |
| Rok vydání: | 2008 |
| Předmět: |
Heart Defects
Congenital Male medicine.medical_specialty Captopril Renal function Angiotensin-Converting Enzyme Inhibitors Blood Pressure 610 Medicine & health medicine Humans 2735 Pediatrics Perinatology and Child Health Neonatology Retrospective Studies Heart Failure Dose-Response Relationship Drug biology business.industry Infant Newborn Infant Obstetrics and Gynecology 2729 Obstetrics and Gynecology Angiotensin-converting enzyme medicine.disease Surgery Treatment Outcome Blood pressure 10036 Medical Clinic Heart failure Anesthesia Pediatrics Perinatology and Child Health ACE inhibitor biology.protein Female Kidney Diseases Hypotension business Kidney disease medicine.drug |
| Zdroj: | Journal of Perinatal Medicine. 36:448-452 |
| ISSN: | 1619-3997 0300-5577 |
| DOI: | 10.1515/jpm.2008.064 |
| Popis: | AIM: To analyze the side effects of captopril, an angiotensin converting enzyme inhibitor (ACEI) in newborn and young infants. METHODS: Retrospective analysis of side effects in 43 patients with congenital heart disease after cardiac surgery treated with captopril for heart failure during a two-year period. RESULTS: Median age of the patients was 26 days (range 6-310 days), median weight 3.5 kg (range 1.9-7.9 kg). Initial median dose of captopril was 0.17 mg/kg/day (range 0.05-0.55 mg/kg/day), slowly increased over 3-33 days to a maximal median dose of 1.86 mg/kg/day (range 0.2-2.3 mg/kg/day). All patients were additionally treated with diuretics. Side effects occurred in 17 patients (renal impairment or failure in 6, low blood pressure in 8, and oxygen saturation deficit in 3) requiring cessation or interruption in seven patients with renal impairment/failure (n=4), hypotension (n=1) and aorto-pulmonary shunting with low pulmonary perfusion (n=2). The six children who developed renal impairment or failure did so following a median delay of nine days after reaching the final dose and weighed on average 500 g less than the other patients (P=0.046). All side effects were fully reversible. CONCLUSION: Side effects due to captopril were not dose-related in newborns and infants in this study. However, renal side effects occurred more often in smaller infants. Routine monitoring of infants on ACEI should include renal function tests, blood pressure and transcutaneous oxygen saturation measurements. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|