Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample
| Autor: | Hannele Laivuori, Sakari Knuutila, Sanna Heino, Juha Kere, Leena Hiltunen, Inkeri Tiala, Vesa Rasi, Katja Kivinen, Hanna Peterson |
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| Rok vydání: | 2007 |
| Předmět: |
Genetic Markers
Candidate gene Placenta Population 030204 cardiovascular system & hematology Biology Genetic determinism Preeclampsia Cohort Studies 03 medical and health sciences 0302 clinical medicine Population Groups Pre-Eclampsia Genetic linkage Pregnancy Genetics medicine Animals Humans Genetic Predisposition to Disease Genetic Testing education Genotyping reproductive and urinary physiology Genetics (clinical) Finland 030304 developmental biology Genetic association Oligonucleotide Array Sequence Analysis 0303 health sciences education.field_of_study Chromosome Genetic Variation Sequence Analysis DNA medicine.disease female genital diseases and pregnancy complications Haplotypes embryonic structures RNA Female Lod Score Carrier Proteins |
| Zdroj: | European journal of human genetics : EJHG. 15(4) |
| ISSN: | 1018-4813 |
| Popis: | Preeclampsia is a common, pregnancy-specific vascular disorder characterised by hypertension and proteinuria. A recent report suggested association of the STOX1 gene on chromosome 10q22.1 with preeclampsia in the Dutch population. Here, we present a comprehensive assessment of STOX1 as a candidate gene for preeclampsia in the Finnish population by re-examining our previous genetic linkage analysis results for both chromosome 10 and paralogous loci, by genotyping representative markers in a nationwide data set, and by studying STOX1 expression in placentas from preeclamptic and uncomplicated pregnancies. In conclusion, we are unable to validate STOX1 as a common preeclampsia susceptibility gene. |
| Databáze: | OpenAIRE |
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