Blockade of acute hypertensive response does not prevent changes in behavior or in CSF acetylcholine (ACH) content following traumatic brain injury (TBI)
| Autor: | Jennifer R. Pascua, Manisha Z. Kapasi, Kelly P. McDowell, Susan E. Robinson, E.Karl Enters, John T. Povlishock |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Traumatic brain injury Central nervous system Posture Blood Pressure Hexamethonium Compounds Motor Activity Blood–brain barrier Axonal Transport Hexamethonium chemistry.chemical_compound Cerebrospinal fluid Neurochemical Escape Reaction Heart Rate medicine Animals Molecular Biology Horseradish Peroxidase Analysis of Variance Behavior Animal business.industry General Neuroscience Brain Rats Inbred Strains medicine.disease Acetylcholine nervous system diseases Blockade Rats medicine.anatomical_structure nervous system chemistry Anesthesia Brain Injuries Hypertension Neurology (clinical) business Developmental Biology medicine.drug |
| Zdroj: | Brain research. 576(2) |
| ISSN: | 0006-8993 |
| Popis: | There is evidence that the blood-brain barrier (BBB) is breached following traumatic brain injury (TBI), allowing the unregulated entry of circulating neuroactive substances into the central nervous system. As the traumatic episode is typically associated with an acute hypertensive event, which in itself may alter BBB status, the effects of the blockade of TBI-associated hypertension on injury-associated behavioral and cerebrospinal fluid (CSF) neurochemical changes were assessed in rats. Animals were injected with either saline or hexamethonium 15 min prior to a moderate fluid percussion injury while under light methoxyflurane anesthesia. This dose of hexamethonium was demonstrated to block the hypertensive response to TBI. Pretreatment with hexamethonium prevented neither acute nor more enduring behavioral deficits observed after TBI. Hexamethonium did not prevent TBI-associated increases in CSF acetylcholine (ACh) content in separate group of rats sampled 12 min following TBI. Furthermore, histological inspection indicated that hexamethonium did not prevent TBI-induced disruption of the BBB, as assessed by intravascular horseradish peroxidase (HRP). Thus, blockade of the hypertensive response to TBI does not afford behavioral protection nor does it prevent changes in the BBB or CSF ACh content following TBI. TBI is in itself sufficient to modify behavior, neurochemistry and BBB function in the absence of hypertension. |
| Databáze: | OpenAIRE |
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