Fetotoxicity of Nanoparticles: Causes and Mechanisms
| Autor: | Xiaojing Liu, Cuijuan Jiang, Sulian Gao, Chuanfeng Teng, Shumei Zhai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
DNA damage
General Chemical Engineering Nanoparticle 02 engineering and technology Review physicochemical properties 010501 environmental sciences medicine.disease_cause 01 natural sciences Placental barrier lcsh:Chemistry medicine General Materials Science 0105 earth and related environmental sciences biological mechanisms Chemistry nanoparticle Autophagy 021001 nanoscience & nanotechnology Cell biology lcsh:QD1-999 Nanotoxicology Apoptosis transplacental transfer Toxicity fetotoxicity 0210 nano-technology Oxidative stress |
| Zdroj: | Nanomaterials, Vol 11, Iss 791, p 791 (2021) Nanomaterials |
| ISSN: | 2079-4991 |
| Popis: | The application of nanoparticles in consumer products and nanomedicines has increased dramatically in the last decade. Concerns for the nano-safety of susceptible populations are growing. Due to the small size, nanoparticles have the potential to cross the placental barrier and cause toxicity in the fetus. This review aims to identify factors associated with nanoparticle-induced fetotoxicity and the mechanisms involved, providing a better understanding of nanotoxicity at the maternal–fetal interface. The contribution of the physicochemical properties of nanoparticles (NPs), maternal physiological, and pathological conditions to the fetotoxicity is highlighted. The underlying molecular mechanisms, including oxidative stress, DNA damage, apoptosis, and autophagy are summarized. Finally, perspectives and challenges related to nanoparticle-induced fetotoxicity are also discussed. |
| Databáze: | OpenAIRE |
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