A one-pot two-step synthesis of tertiary alcohols combining the biocatalytic laccase/TEMPO oxidation system with organolithium reagents in aerobic aqueous media at room temperature
| Autor: | Alejandro Presa Soto, Vito Capriati, Joaquín García-Álvarez, Marina Ramos-Martín, Nicolás Ríos-Lombardía, Ramón Lecuna, Javier González-Sabín, Paola Vitale, Luciana Cicco |
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| Rok vydání: | 2021 |
| Předmět: |
Laccase
Aqueous medium Two step Metals and Alloys Substrate (chemistry) General Chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound chemistry Catalytic oxidation Reagent Materials Chemistry Ceramics and Composites Organic chemistry Tertiary alcohols Organometallic chemistry |
| Zdroj: | Chemical Communications. 57:13534-13537 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | The one-pot/two-step combination of enzymes and polar organometallic chemistry in aqueous media is for the first time presented as a proof-of-concept study. The unprecedented combination of the catalytic oxidation of secondary alcohols by the system laccase/TEMPO with the ultrafast addition (3 s reaction time) of polar organometallic reagents (RLi/RMgX) to the in situ formed ketones, run under air at room temperature, allows the straightforward and chemoselective synthesis of tertiary alcohols with broad substrate scope and excellent conversions (up to 96%). |
| Databáze: | OpenAIRE |
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