Levels of sICAM-1, sVCAM-1 and MCP-1 in patients with hyperlipoproteinemia IIa and -IIb
| Autor: | Kalina Z, K. Makowiecka, Marek Zieliński, A Madej, Jan Kowalski, Bogusław Okopień, Zbigniew S. Herman |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Chemokine Intercellular Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Enzyme-Linked Immunosorbent Assay Hyperlipoproteinemia Type II Internal medicine Blood plasma medicine Humans Pharmacology (medical) Cell adhesion Chemokine CCL2 Triglycerides Aged Apolipoproteins B Pharmacology biology Cell adhesion molecule Chemistry Monocyte Adhesion Middle Aged Endocrinology medicine.anatomical_structure Cholesterol biology.protein Female Intracellular |
| Zdroj: | International journal of clinical pharmacology and therapeutics. 39(2) |
| ISSN: | 0946-1965 |
| Popis: | OBJECTIVE Hyperlipoproteinemia is one of the factors that are involved in the development of atherosclerosis. One of the mechanisms through which these high plasma lipid levels trigger the formation of atherosclerotic lesions is a change in the expression of adhesion molecules on endothelial and smooth muscle cells. The aim of this study was to evaluate the plasma levels of soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and monocyte chemoattractant protein-1 (MCP-1) in patients with Type IIa (HLP-IIa) and IIb (HLP-IIb) hyperlipoproteinemias. SUBJECTS Twenty patients with HLP-IIa, 20 patients with HLP-IIb and 23 control subjects were studied. To accurately evaluate adhesion molecule levels, we excluded those hyperlipemic patients and control subjects who had an inflammatory disease. METHODS Plasma sICAM-1, sVCAM-1 and MCP-1 levels were measured by the ELISA method. RESULTS sVCAM-1 levels in HLP-IIa and HLP-IIb patients (535 +/- 27 ng/ml and 545 +/- 22 ng/ml, respectively) did not differ significantly from those in the control group (558 +/- 20 ng/ml). sICAM-1 levels were significantly higher in patients with HLP-IIa and HLP-IIb (279 +/- 10 ng/ml and 322 +/- 12 ng/ml, respectively) compared to the control group (226 +/- 10 ng/ml). MCP-1 levels were significantly higher in HLP-IIa and HLP-IIb patients (151 +/- 12 pg/ml vs 154 +/- 12 pg/ml, respectively) compared to healthy controls (98 +/- 4 pg/ml). sICAM-1 levels in the HLP-IIb group were significantly higher than in the HLP-IIa group. CONCLUSION The results of the study suggest that lipid abnormalities affect the levels of adhesion molecules and chemokines in plasma. |
| Databáze: | OpenAIRE |
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