Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine-deficient rats
| Autor: | Barbara Plecko, C. Stromberger, C.A.J.M. Jakobs, S. Stoeckler-Ipsiroglu, M. Leschnik, A. Muehl, Eduard A. Struys, H. Hoeger |
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| Přispěvatelé: | VU University medical center |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Central nervous system Biology chemistry.chemical_compound Epilepsy Internal medicine Genetics medicine Animals Pyridoxine Deficiency Pyridoxal phosphate Genetics (clinical) Pipecolic acid Brain Pyridoxine Metabolism medicine.disease Vitamin B 6 Rats Disease Models Animal B vitamins medicine.anatomical_structure Endocrinology chemistry Pipecolic Acids Pyridoxal Phosphate Animal Nutritional Physiological Phenomena Female Metabolism Inborn Errors medicine.drug |
| Zdroj: | Plecko, B, Hoeger, H, Jakobs, C A J M, Struys, E A, Stromberger, C, Leschnik, M, Muehl, A & Stockler-Ipsiroglu, S 2005, ' Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine-deficient rats ', Journal of Inherited Metabolic Disease, vol. 28, no. 5, pp. 689-693 . https://doi.org/10.1007/s10545-005-0071-4 Journal of Inherited Metabolic Disease, 28(5), 689-693. Springer Netherlands |
| ISSN: | 0141-8955 |
| DOI: | 10.1007/s10545-005-0071-4 |
| Popis: | Elevated concentrations of pipecolic acid have been reported in plasma and CSF of patients with pyridoxine-dependent epilepsy, but its molecular background is unclear. To investigate any further association of pyridoxine and pipecolic acid metabolism, we have performed an animal trial and have measured the concentration of pipecolic acid in brain tissue of rats with nutritional pyridoxine deficiency and in control littermates. Concentrations of pyridoxal phosphate were significantly reduced in brain tissue of pyridoxine-deficient rats (p < 0.001), while concentrations of pipecolic acid were not significantly different from the normally nourished control group (p = 0.3). These data indicate that a direct association of pyridoxine and pipecolic acid metabolism is unlikely. We therefore assume that the characteristic elevation of pipecolic acid in pyridoxine-dependent epilepsy could rather be a secondary phenomenon with the primary defect of pyridoxine-dependent epilepsy being located outside the pipecolic acid pathway. |
| Databáze: | OpenAIRE |
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