Sperm, Nuclear, Phospholipid, and Red Blood Cell Antibodies and Isotype RF in Infertile Couples and Patients With Autoimmune Rheumatic Diseases
| Autor: | L. Nakov, Raina N. Fichorova, K. Nikolov, M. Baleva, I. Gegova |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Erythrocytes Adolescent Anti-nuclear antibody Immunology medicine.disease_cause Autoimmune Diseases Autoimmunity Arthritis Rheumatoid Rheumatoid Factor medicine Humans Immunology and Allergy Unexplained infertility biology Immune Sera Autoantibody Obstetrics and Gynecology Sperm Agglutination Spermatozoa Isotype Immunoglobulin Isotypes Reproductive Medicine Polyclonal antibodies Antibodies Antinuclear Infertility Antibodies Antiphospholipid biology.protein Female Antibody |
| Zdroj: | American Journal of Reproductive Immunology. 36:309-316 |
| ISSN: | 1046-7408 |
| Popis: | PROBLEM : To determine if measuring of nonorgan-specific autoantibodies is useful for better understanding and management of unexplained infertility. METHODS : Sera were obtained from 70 infertile couples, 57 rheumatic patients, and 76 fertile donors. Sperm antibodies (SA) were detected by the tests of Kibrick and Friberg, anti-histones, anti-cardiolipin antibodies, and RF isotypes by ELISA, antinuclear antibodies by indirect immunofluorescence, and anti-red blood cell antibodies by Capture-R. RESULTS : Multiple autoimmune reactivity (both partners positive and/or more than one type of autoantibody involved), higher than naturally occurring in fertile individuals, was found in 55% of the idiopathically infertile couples. IgA-RF was the dominant autoimmune marker. SA revealed similar rates in patients with rheumatic diseases and in infertiles with or without other autoantibodies. CONCLUSION : Although no single autoimmunity marker could predict occurrence of SA, the coincidence of enhanced polyclonal autoimmunity in both partners of infertile couples might potentiate their negative effect on reproduction. |
| Databáze: | OpenAIRE |
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