Products of Cartilage Metabolism
| Autor: | E J Thonar, Jean-Pierre Devogelare, Daniel-Henri Manicourt |
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| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Dynamics of Bone and Cartilage Metabolism Dynamics of Bone and Cartilage Metabolism (Second Edition) |
| DOI: | 10.1016/b9-78-012088-5/62650-0261 |
| Popis: | This chapter discusses the major products of articular cartilage metabolism with special emphasis on those that are relevant as body fluid markers. It provides a brief review of the structure–function relationships of the major matrix building blocks. The cartilage matrix contains several molecules that are found in much higher concentrations than in other tissues. The attention that aggrecan and collagen type II are currently receiving as potential markers of specific metabolic alterations in cartilage disease will likely extend to less abundant molecules found to play key roles in the maintenance of matrix homeostasis. As the understanding of the function and metabolism of these molecules improves, so will their potential as markers of the irreversible destabilization of the collagenous meshwork or of other specific alterations in cartilage matrix organization. |
| Databáze: | OpenAIRE |
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