Ameliorating effect of continuous alpha-glycosyl isoquercitrin treatment starting from late gestation in a rat autism model induced by postnatal injection of lipopolysaccharides
| Autor: | Hiromu Okano, Kazumi Takashima, Yasunori Takahashi, Ryota Ojiro, Qian Tang, Shunsuke Ozawa, Bunichiro Ogawa, Mihoko Koyanagi, Robert R. Maronpot, Toshinori Yoshida, Makoto Shibutani |
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| Rok vydání: | 2021 |
| Předmět: |
Lipopolysaccharides
Male Neurogenesis Anti-Inflammatory Agents Social Interaction Gene Expression General Medicine Toxicology Antioxidants Rats Sprague-Dawley Oxidative Stress Neuroprotective Agents Animals Newborn Pregnancy Dentate Gyrus Neuroinflammatory Diseases Animals Female Quercetin Glycosides Autistic Disorder Open Field Test |
| Zdroj: | Chemico-biological interactions. 351 |
| ISSN: | 1872-7786 |
| Popis: | The present study investigated the role of neuroinflammation and brain oxidative stress induced by neonatal treatment with lipopolysaccharides (LPS) on the development of autism spectrum disorder (ASD)-like behaviors and disruptive hippocampal neurogenesis in rats by exploring the chemopreventive effects of alpha-glycosyl isoquercitrin (AGIQ) as an antioxidant. AGIQ was dietary administered to dams at 0.25% or 0.5% (w/w) from gestational day 18 until postnatal day (PND) 21 on weaning and then to pups until the adult stage on PND 77. The pups were intraperitoneally injected with LPS (1 mg/kg body weight) on PND 3. At PND 6, LPS alone increased Iba1 |
| Databáze: | OpenAIRE |
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