Analysis of convective and diffusive transport in the brain interstitium
Autor: | Jeffrey J. Iliff, Lori Ray, Jeffrey J. Heys |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Convection Work (thermodynamics) Convective flow Extracellular transport Flow (psychology) Finite Element Analysis Models Neurological Brain tissue Biotransport lcsh:RC346-429 Diffusion 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Developmental Neuroscience Animals Computer Simulation lcsh:Neurology. Diseases of the nervous system Bulk flow Physics Research Brain Biological Transport General Medicine Mechanics Convective velocity 030104 developmental biology Neurology Parenchyma Hydrodynamics Current (fluid) Real time iontophoresis 030217 neurology & neurosurgery Algorithms Finite element model |
Zdroj: | Fluids and Barriers of the CNS Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-18 (2019) |
ISSN: | 2045-8118 |
Popis: | Background Despite advances in in vivo imaging and experimental techniques, the nature of transport mechanisms in the brain remain elusive. Mathematical modelling verified using available experimental data offers a powerful tool for investigating hypotheses regarding extracellular transport of molecules in brain tissue. Here we describe a tool developed to aid in investigation of interstitial transport mechanisms, especially the potential for convection (or bulk flow) and its relevance to interstitial solute transport, for which there is conflicting evidence. Methods In this work, we compare a large body of published experimental data for transport in the brain to simulations of purely diffusive transport and simulations of combined convective and diffusive transport in the brain interstitium, incorporating current theories of perivascular influx and efflux. Results The simulations show (1) convective flow in the interstitium potentially of a similar magnitude to diffusive transport for molecules of interest and (2) exchange between the interstitium and perivascular space, whereby fluid and solutes may enter or exit the interstitium, are consistent with the experimental data. Simulations provide an upper limit for superficial convective velocity magnitude (approximately \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$v$$\end{document}v = 50 μm min−1), a useful finding for researchers developing techniques to measure interstitial bulk flow. Conclusions For the large molecules of interest in neuropathology, bulk flow may be an important mechanism of interstitial transport. Further work is warranted to investigate the potential for bulk flow. Electronic supplementary material The online version of this article (10.1186/s12987-019-0126-9) contains supplementary material, which is available to authorized users. |
Databáze: | OpenAIRE |
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