Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip
| Autor: | Kyung J. Ahn, Charles de Charleroy, E. Bryan Crenshaw, Lihua Qin, Lara Wine Lee |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cerebellum Cell signaling Physiology Sensory Physiology Gene Expression Signal transduction Gene Knockout Techniques Mice 0302 clinical medicine Nerve Fibers Animal Cells Inferior olivary nucleus Medicine and Health Sciences Mossy fiber (cerebellum) Rhombic lip Mice Knockout Neurons Cerebral Cortex Multidisciplinary Gene Expression Regulation Developmental Brain Sensory Systems Cell biology medicine.anatomical_structure Auditory System embryonic structures Bone Morphogenetic Proteins Medicine Anatomy Cellular Types Neural development Research Article animal structures BMP signaling Science Neurogenesis Cerebellar mossy fiber Hindbrain Biology Bone morphogenetic protein 03 medical and health sciences medicine Genetics Animals Bone Morphogenetic Protein Receptors Type I Auditory Pathway Biology and Life Sciences Rhombencephalon 030104 developmental biology nervous system Cellular Neuroscience Climbing Fibers 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 14, Iss 12, p e0226602 (2019) |
| ISSN: | 1932-6203 |
| Popis: | Bone morphogenetic proteins (BMPs) have been hypothesized to specify distinct dorsal neural fates. During neural development, BMPs are expressed in the roof plate and adjacent neuroepithelium. Because several hindbrain nuclei that form the proprioceptive/vestibular/auditory sensory network originate from the rhombic lip, near the roof plate, BMP signaling may regulate the development of these nuclei. To test this hypothesis genetically, we have examined the development of the hindbrain in BMP type I receptor knockout mice. Our results demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei, which give rise to cerebellar mossy fibers, but is not required for the development of the inferior olivary nucleus, which gives rise to cerebellar climbing fibers. |
| Databáze: | OpenAIRE |
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