Interaction between chlorhexidine and fluoride in a mouthrinse solution—a 4-day and 6-week randomized clinical pilot study
| Autor: | Hidekazu Fukui, Dowen Birkhed, Per Ramberg, Claes-Göran Emilson, Lars Heijl, Georgios Papanikolaou, Oscar Villa |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male inorganic chemicals Saliva Adolescent Dental Plaque Mouthwashes Dentistry Pilot Projects Dental plaque Placebo Tooth brushing 03 medical and health sciences chemistry.chemical_compound Gingivitis 0302 clinical medicine Double-Blind Method Sodium fluoride medicine Humans Drug Interactions General Dentistry Cross-Over Studies business.industry Chlorhexidine technology industry and agriculture 030206 dentistry medicine.disease Healthy Volunteers body regions chemistry Anti-Infective Agents Local Sodium Fluoride Female 030211 gastroenterology & hepatology medicine.symptom business Fluoride medicine.drug |
| Zdroj: | Clinical Oral Investigations. 22:1439-1448 |
| ISSN: | 1436-3771 1432-6981 |
| Popis: | The aim of the present investigation was to study if there is a reduced clinical effect and fluoride retention of a mouthrinse solution containing both chlorhexidine (CHX) and sodium fluoride (NaF). Two clinical trials were designed as double-blind, randomized, cross-over studies. In study I, 16 healthy subjects were asked to rinse twice daily for 1 min during 4 days of no tooth brushing with four solutions: (1) 0.12% CHX + 0.2% NaF, (2) 0.2% NaF, (3) 0.12% CHX, and (4) placebo. In study II, another 16 healthy subjects rinsed with the same four solutions twice daily after tooth brushing during a 6-week period. Plaque formation, gingivitis, and microbiological samples from plaque and saliva, as well as fluoride retention, were analyzed. Both studies showed that both CHX + NaF and CHX mouthrinses had the same clinical effect with regards to plaque formation and microflora in plaque and saliva. Similarly, fluoride retention was not altered by the CHX + NaF mouthrinse compared to the NaF solution. The combination of CHX and NaF in a mouthrinse showed the same clinical effect as the CHX solution. The retention of fluoride in the oral cavity was not affected by the combination of NaF and CHX. A mouthrinse solution containing a mixture of CHX and NaF may be an interesting product for risk patients for caries and periodontal disease. However, this should be verified in further long-term clinical studies. |
| Databáze: | OpenAIRE |
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