In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT)
| Autor: | Enock Jonathan, Joey Enfield, Martin J. Leahy |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test Image quality business.industry Image registration Image processing Atomic and Molecular Physics and Optics Microcirculation medicine.anatomical_structure Forearm Optical coherence tomography ocis:(170.4500) Optical coherence tomography medicine sense organs Speckle imaging Optical Coherence Tomography ocis:(170.3880) Medical and biological imaging business Preclinical imaging Biotechnology Biomedical engineering |
| Zdroj: | Biomedical Optics Express |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/boe.2.001184 |
| Popis: | Correlation mapping optical coherence tomography (cmOCT) is a recently proposed technique that extends the capabilities of OCT to enable mapping of vasculature networks. The technique is achieved as a processing step on OCT intensity images that does not require any modification to existing OCT hardware. In this paper we apply the cmOCT processing technique to in vivo human imaging of the volar forearm. We illustrate that cmOCT can produce maps of the microcirculation that clearly follow the accepted anatomical structure. We demonstrate that the technique can extract parameters such as capillary density and vessel diameter. These parameters are key clinical markers for the early changes associated with microvascular diseases. Overall the presented results show that cmOCT is a powerful new tool that generates microcirculation maps in a safe non-invasive, non-contact technique which has clear clinical applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|