Association between treatment-related lymphopenia and overall survival in elderly patients with newly diagnosed glioblastoma
| Autor: | Joe S. Mendez, Jacqueline Leong, Ashwin Govindan, Jiayi Huang, Jian Campian, Feng Gao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty medicine.medical_treatment Article 03 medical and health sciences 0302 clinical medicine Internal medicine Lymphopenia medicine Temozolomide Humans Prospective cohort study Survival rate Antineoplastic Agents Alkylating Aged Retrospective Studies Aged 80 and over Chemotherapy business.industry Brain Neoplasms Cancer Immunosuppression Retrospective cohort study Radiotherapy Dosage Chemoradiotherapy medicine.disease Prognosis Surgery Dacarbazine Survival Rate Neurology 030220 oncology & carcinogenesis Female Neurology (clinical) Neoplasm Grading business Glioblastoma 030217 neurology & neurosurgery medicine.drug Follow-Up Studies |
| Popis: | Management of patients with glioblastoma (GBM) often includes radiation (RT) and temozolomide (TMZ). The association between severe treatment-related lymphopenia (TRL) after the standard chemoradiation and reduced survival has been reported in GBM patients with the median age of 57. Similar findings were described in patients with head and neck, non-small cell lung, and pancreatic cancers. This retrospective study is designed to evaluate whether elderly GBM patients (age ≥65) develop similar TRL after RT/TMZ and whether such TRL is associated with decreased survival. Serial total lymphocyte counts (TLC) were retrospectively reviewed in patients (age ≥65) with newly diagnosed GBM undergoing RT/TMZ and associated with treatment outcomes. Seventy-two patients were eligible: median KPS 70, median age 71 years (range 65-86) with 56 % of patients >70 years, 53% female, 31% received RT ≤45 Gy. Baseline median TLC was 1100 cells/mm(3) which fell by 41% to 650 cells/mm(3) 2 months after initiating RT/TMZ (p < 0.0001). Patients with TLC |
| Databáze: | OpenAIRE |
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