On the mechanical analogue of DNA
| Autor: | Ludmila V. Yakushevich |
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| Rok vydání: | 2016 |
| Předmět: |
Models
Molecular Base pair Biophysics Complex system Rigidity (psychology) 01 natural sciences 010305 fluids & plasmas chemistry.chemical_compound Gravitational field Chain (algebraic topology) Bacteriophage T7 0103 physical sciences 010306 general physics Molecular Biology Mechanical Phenomena Physics chemistry.chemical_classification Sequence Original Paper Base Sequence Biomolecule Cell Biology DNA Atomic and Molecular Physics and Optics Biomechanical Phenomena Classical mechanics chemistry Nucleic Acid Conformation |
| Zdroj: | Journal of biological physics. 43(1) |
| ISSN: | 1573-0689 |
| Popis: | The creation of mechanical analogues of biological systems is known as a useful instrument that helps to understand better the dynamical mechanisms of the functioning of living organisms. Mechanical analogues of biomolecules are usually constructed for imitation of their internal mobility, which is one of the most important properties of the molecules. Among the different types of internal motions, angular oscillations of nitrous bases are of special interest because they make a substantial contribution to the base pairs opening that in turn is an important element of the process of the DNA–protein recognition. In this paper, we investigate the possibility to construct a mechanical analogue for imitation of angular oscillations of nitrous bases in inhomogeneous DNA. It is shown that the analogue has the form of a mechanical chain of non-identical pendulums that oscillate in the gravitational field of the Earth and coupled by identical springs. The masses and lengths of pendulums, as well as the distances between neighboring pendulums and the rigidity of springs are calculated. To illustrate the approach, we present the result of construction of the mechanical analogue of the fragment of the sequence of bacteriophage T7D. |
| Databáze: | OpenAIRE |
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