Impact of ursodeoxycholic acid on circulating lipid concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials

Autor: Arrigo F G Cicero, Maria-Corina Serban, Adriana Sánchez-García, Luis E. Simental-Mendía, Mario Simental-Mendía, Amirhossein Sahebkar, Maciej Banach
Přispěvatelé: Luis E. Simental-Mendía, Mario Simental-Mendía, Adriana Sánchez-García, Maciej Banach, Maria-Corina Serban, Arrigo F. G. Cicero, Amirhossein Sahebkar
Jazyk: angličtina
Rok vydání: 2019
Předmět:
medicine.medical_specialty
HDL
Clinical chemistry
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
030209 endocrinology & metabolism
Clinical nutrition
Review
030204 cardiovascular system & hematology
Placebo
Gastroenterology
Triglyceride
law.invention
LDL
03 medical and health sciences
0302 clinical medicine
Endocrinology
Primary biliary cirrhosis
Randomized controlled trial
law
Internal medicine
Medicine
Humans
Meta-analysi
Total cholesterol
lcsh:RC620-627
Triglycerides
Hypolipidemic Agents
Randomized Controlled Trials as Topic
medicine.diagnostic_test
business.industry
Biochemistry (medical)
Cholesterol
HDL
Ursodeoxycholic acid
Cholesterol
LDL
medicine.disease
Lipid Metabolism
Lipids
Lipid profile
Meta-analysis
lcsh:Nutritional diseases. Deficiency diseases
business
medicine.drug
Zdroj: Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-13 (2019)
Lipids in Health and Disease
DOI: 10.1186/s12944-019-1041-4
Popis: Objective: The aim of this meta-analysis of randomized placebo-controlled trials was to examine whether ursodeoxycholic acid treatment is an effective lipid-lowering agent. Methods: PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched in order to find randomized controlled trials evaluating the effect of ursodeoxycholic acid on lipid profile. A random-effect model and the generic inverse variance weighting method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A random-effects meta-regression model was performed to explore the association between potential confounders and the estimated effect size on plasma lipid concentrations. Results: Meta-analysis of 20 treatment arms revealed a significant reduction of total cholesterol following ursodeoxycholic acid treatment (WMD: - 13.85 mg/dL, 95% CI: -21.45, - 6.25, p < 0.001). Nonetheless, LDL-C (WMD: -6.66 mg/dL, 95% CI: -13.99, 0.67, p = 0.075), triglycerides (WMD: - 1.42 mg/dL, 95% CI: -7.51, 4.67, p = 0.648) and HDL-C (WMD: -0.18 mg/dL, 95% CI: -5.23, 4.87, p = 0.944) were not found to be significantly altered by ursodeoxycholic acid administration. In the subgroup of patients with primary biliary cirrhosis, ursodeoxycholic acid reduced total cholesterol (WMD: - 29.86 mg/dL, 95% CI: -47.39, - 12.33, p = 0.001) and LDL-C (WMD: -37.27 mg/dL, 95% CI: -54.16, - 20.38, p < 0.001) concentrations without affecting TG and HDL-C. Conclusion: This meta-analysis suggests that ursodeoxycholic acid therapy might be associated with significant total cholesterol lowering particularly in patients with primary biliary cirrhosis.
Databáze: OpenAIRE
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