Evolution of sequence-specific anti-silencing systems in Arabidopsis
Autor: | Akira Kawabe, Sasaki Taku, Aoi Hosaka, Tasuku Ito, Asao Fujiyama, Yu Fu, Raku Saito, Atsushi Toyoda, Tetsuji Kakutani, Kazuya Takashima, Yoshiaki Tarutani |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Transposable element Science Arabidopsis General Physics and Astronomy Computational biology Genome General Biochemistry Genetics and Molecular Biology Article Evolution Molecular 03 medical and health sciences Molecular evolution Gene Expression Regulation Plant Sequence Homology Nucleic Acid Epigenetics Gene Silencing Nucleotide Motifs lcsh:Science Epigenomics Regulation of gene expression Multidisciplinary biology Base Sequence Arabidopsis Proteins food and beverages General Chemistry DNA Methylation biology.organism_classification 030104 developmental biology DNA methylation DNA Transposable Elements Trans-Activators lcsh:Q Genome Plant |
Zdroj: | Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017) Nature Communications |
ISSN: | 2041-1723 |
Popis: | The arms race between parasitic sequences and their hosts is a major driving force for evolution of gene control systems. Since transposable elements (TEs) are potentially deleterious, eukaryotes silence them by epigenetic mechanisms such as DNA methylation. Little is known about how TEs counteract silencing to propagate during evolution. Here, we report behavior of sequence-specific anti-silencing proteins used by Arabidopsis TEs and evolution of those proteins and their target sequences. We show that VANC, a TE-encoded anti-silencing protein, induces extensive DNA methylation loss throughout TEs. Related VANC proteins have evolved to hypomethylate TEs of completely different spectra. Targets for VANC proteins often form tandem repeats, which vary considerably between related TEs. We propose that evolution of VANC proteins and their targets allow propagation of TEs while causing minimal host damage. Our findings provide insight into the evolutionary dynamics of these apparently “selfish” sequences. They also provide potential tools to edit epigenomes in a sequence-specific manner. Eukaryotes often silence transposable elements (TEs) via DNA methylation. Here, the authors show that evolution of VANC, an Arabidopsis anti-silencing factor, and its target motifs allows sequence-specific demethylation, suggesting a way TEs can proliferate while minimizing damage to the host genome. |
Databáze: | OpenAIRE |
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