Characteristics and outcomes of hospitalised adults with COVID-19 in a Global Health Research Network: a cohort study
| Autor: | Kathleen Gondek, Corinne G. Brooks, Ajit A. Londhe, Giovanna Devercelli, Qian Xia, Brian D. Bradbury, Zhongyuan Wei, Xiu Chen, Ying Bao, Linyun Zhou, Kaili Ren, Hillary A Keenan, Peter Yu, Olulade Ayodele, Lynn Sanders, Michele Jonsson-Funk, Junjie Ma, Jie Zhang, Alvan Cheng, Manasi Suryavanshi, Cathy W. Critchlow, Jenny Jiang, Julia Zhu, Vivek Gandhi, Carolyn A. Brown, Sudhakar Manne |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty ARDS Adolescent Population Global Health infectious diseases law.invention Cohort Studies Young Adult law Epidemiology medicine Humans Young adult education Pandemics education.field_of_study SARS-CoV-2 business.industry COVID-19 General Medicine medicine.disease Respiration Artificial Intensive care unit Hospitalization Intensive Care Units Respiratory failure Cohort Emergency medicine Medicine Female epidemiology Public Health business Cohort study |
| Zdroj: | BMJ Open, Vol 11, Iss 8 (2021) BMJ Open |
| ISSN: | 2044-6055 |
| DOI: | 10.1136/bmjopen-2021-051588 |
| Popis: | ObjectiveTo examine age, gender, and temporal differences in baseline characteristics and clinical outcomes of adult patients hospitalised with COVID-19.DesignA cohort study using deidentified electronic medical records from a Global Research Network.Setting/Participants67 456 adult patients hospitalised with COVID-19 from the USA; 7306 from Europe, Latin America and Asia-Pacific between February 2020 and January 2021.ResultsIn the US cohort, compared with patients 18–34 years old, patients ≥65 had a greater risk of intensive care unit (ICU) admission (adjusted HR (aHR) 1.73, 95% CI 1.58 to 1.90), acute respiratory distress syndrome(ARDS)/respiratory failure (aHR 1.86, 95% CI 1.76 to 1.96), invasive mechanical ventilation (IMV, aHR 1.93, 95% CI, 1.73 to 2.15), and all-cause mortality (aHR 5.6, 95% CI 4.36 to 7.18). Men appeared to be at a greater risk for ICU admission (aHR 1.34, 95% CI 1.29 to 1.39), ARDS/respiratory failure (aHR 1.24, 95% CI1.21 to 1.27), IMV (aHR 1.38, 95% CI 1.32 to 1.45), and all-cause mortality (aHR 1.16, 95% CI 1.08 to 1.24) compared with women. Moreover, we observed a greater risk of adverse outcomes during the early pandemic (ie, February–April 2020) compared with later periods. In the ex-US cohort, the age and gender trends were similar; for the temporal trend, the highest proportion of patients with all-cause mortality were also in February–April 2020; however, the highest percentages of patients with IMV and ARDS/respiratory failure were in August–October 2020 followed by February–April 2020.ConclusionsThis study provided valuable information on the temporal trends of characteristics and outcomes of hospitalised adult COVID-19 patients in both USA and ex-USA. It also described the population at a potentially greater risk for worse clinical outcomes by identifying the age and gender differences. Together, the information could inform the prevention and treatment strategies of COVID-19. Furthermore, it can be used to raise public awareness of COVID-19’s impact on vulnerable populations. |
| Databáze: | OpenAIRE |
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