Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin

Autor:	Dag Ilver, James G. Fox, Martin J. Blaser, Robert H. Gilman, Marina Aspholm-Hurtig, Jafar Mahdavi, Ingemar Carlstedt, Anna Bäckström, Manuel López-Brea, Awdhesh Kalia, Thomas Borén, Billie Velapatiño, Sara Lindén, Guillermo I. Perez-Perez, Susanne Vikström, Niamh Roche, Stefan Oscarson, Ulf J. Nilsson, Martina Lahmann, Maria Gloria Dominguez-Bello, Giedrius Dailide, Susann Teneberg, Staffan Normark, Douglas E. Berg, Anna Arnqvist, Pelayo Correa, Teresa Alarcón, Carina Lundberg, Rolf Sjöström, Markus Gerhard, Teruko Nakazawa
Rok vydání:	2004
Předmět:	Molecular Sequence Data Adaptation Biological Plasma protein binding Biology Bacterial Adhesion Fucose ABO Blood-Group System Helicobacter Infections Microbiology Bacterial genetics Evolution Molecular chemistry.chemical_compound Lewis Blood Group Antigens ABO blood group system Peru Humans Selection Genetic Binding site Allele Adhesins Bacterial Alleles Phylogeny Binding Sites Multidisciplinary Base Sequence Helicobacter pylori Indians South American biology.organism_classification Bacterial adhesin Phenotype chemistry Gastric Mucosa Mutation Transformation Bacterial Protein Binding
Zdroj:	Science. 305:519-522
ISSN:	1095-9203 0036-8075
Popis:	Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O–dominant human populations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afdb64597a930a51e2717d0f10a3a85 https://doi.org/10.1126/science.1098801 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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