Vagotomy effect on gastric prostaglandins. Primarily neural or secondary to hypoacidity?
| Autor: | Barry A. Levine, Kenneth R. Sirinek, Luke J. Curtsinger |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Atropine
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Prostaglandin Dinoprostone Gastric Acid chemistry.chemical_compound Stress Physiological Vagotomy Truncal Internal medicine medicine Anticholinergic Animals Stomach Ulcer Cimetidine Receptor business.industry Rats Inbred Strains Vagotomy Cytoprotection Epoprostenol Rats Endocrinology chemistry Gastric Mucosa Surgery business Histamine medicine.drug |
| Zdroj: | Archives of surgery (Chicago, Ill. : 1960). 125(4) |
| ISSN: | 0004-0010 |
| Popis: | • Prostaglandins have been implicated in gastric mucosal cytoprotection. Vagotomy results in both cytoprotection and increased mucosal prostaglandin concentrations. However, the mechanism by which vagotomy affects prostaglandin generation remains unknown. In this study we compared vagotomy with long-term acid suppression using anticholinergic (atropine sulfate) or histamine 2 -receptor antagonism (cimetidine) and assessed mucosal injury and prostaglandin generation during graded stress. Vagotomy correlated with decreases in injury only in severe stress, while both atropine and cimetidine decreased injury also during moderate stress. Prostaglandin generation decreased in all groups during severe stress. Compared with sham operation, vagotomy, atropine, and cimetidine were all associated with increased mucosal prostaglandin generation in all stress periods. During severe stress, both atropine and cimetidine also evidenced higher prostaglandin generation than did vagotomy. These results suggest that vagotomy primarily decreases acid secretion, which then secondarily results in increased mucosal generation. ( Arch Surg . 1990;125:457-459) |
| Databáze: | OpenAIRE |
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