Comparative effectiveness of topically applied non-steriod anti-inflammatory agents on guinea-pig skin
| Autor: | A.P. Brock, I. Sarkany, P.M. Gaylarde |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.drug_class
business.industry Administration Topical Guinea Pigs Anti-Inflammatory Agents Prostaglandin synthesis Human skin Inflammation Dermatology Pharmacology Inhibitory postsynaptic potential Skin Diseases Antioxidants Anti-inflammatory Guinea pig Irritants medicine Animals medicine.symptom business Epidermal thickening |
| Zdroj: | Clinical and Experimental Dermatology. 6:373-377 |
| ISSN: | 1365-2230 0307-6938 |
| Popis: | Summary We have tested eleven non-steroid anti-inflammatory agents and two antioxidants, known to have prostaglandin synthesis inhibitory activity, for their ability to suppress irritant-induced epidermal thickening in the guinea-pig. We have found that salicylates and indomethacin were the most active. From previous experience, this activity is thought to correspond to the behaviour of these drugs in human skin. No anti-inflammatory activity was demonstrated by the antioxidants and therefore the unifying concept of prostaglandin synthesis inhibition as an explanation for suppression of inflammation is questioned. |
| Databáze: | OpenAIRE |
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