An immunocompetent farmer with isolated cerebral alveolar echinococcosis: illustrative case
| Autor: | Markus Florian Oertel, Anna Maria Reuss, Oliver Bozinov, Marisa B. Kaelin, Felix Grimm, Michael Reinehr, Marie-Angela Wulf, Anna Henzi, Elisabeth J. Rushing |
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| Přispěvatelé: | University of Zurich |
| Rok vydání: | 2021 |
| Předmět: |
10078 Institute of Parasitology
Pathology medicine.medical_specialty Necrosis medicine.diagnostic_test business.industry Central nervous system 10208 Institute of Neuropathology 610 Medicine & health Histology Alveolar echinococcosis General Medicine medicine.disease Echinococcosis Serology 10234 Clinic for Infectious Diseases 10180 Clinic for Neurosurgery medicine.anatomical_structure Magnetic resonance imaging of the brain medicine Immunohistochemistry medicine.symptom business |
| Zdroj: | Journal of Neurosurgery: Case Lessons. 1 |
| ISSN: | 2694-1902 |
| DOI: | 10.3171/case2187 |
| Popis: | BACKGROUND Alveolar echinococcosis is a rare condition, but living or working in a rural environment is a substantial risk factor. The liver is the organ primarily affected, with additional extrahepatic manifestations in approximately 25% of cases. Primary extrahepatic disease is rare, and isolated cerebral involvement is extremely unusual. OBSERVATIONS The authors described an illustrative case of isolated cerebral alveolar echinococcosis in an immunocompetent farmer. Magnetic resonance imaging of the brain showed a predominantly cystic lesion with perifocal edema and a “bunch of grapes” appearance in the left frontal lobe. Histology revealed sharply demarcated fragments of a fibrous cyst wall accompanied by marked inflammation and necrosis. Higher magnification showed remnants of protoscolices with hooklets and calcified corpuscles. Immunohistochemistry and polymerase chain reaction (PCR) analysis confirmed the diagnosis of cerebral alveolar echinococcosis. Interestingly, serology and thoracic and abdominal computed tomography results were negative, indicative of an isolated primary extrahepatic manifestation. LESSONS Isolated, primary central nervous system echinococcosis is extremely rare, with only isolated case reports. As in the authors’ case, it can occur in immunocompetent patients, especially persons with a rural vocational history. Negative serology results do not exclude cerebral echinococcosis, which requires histological confirmation. Immunohistochemical staining and PCR analysis are especially useful in cases without classic morphological findings. |
| Databáze: | OpenAIRE |
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