Anaerobic Function of CNS White Matter Declines with Age
| Autor: | Thomas Möller, Bruce R. Ransom, Margaret A. Hamner |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Aging
medicine.medical_specialty Central nervous system Action Potentials Biology Neurotransmission Synaptic Transmission Central nervous system disease White matter Mice Oxygen Consumption Internal medicine medicine Animals Anaerobiosis Hypoxia Brain Electrodes Brain Chemistry Brain Electroencephalography Optic Nerve Hypoxia (medical) medicine.disease Axons Electrophysiological Phenomena Compound muscle action potential Mice Inbred C57BL Endocrinology medicine.anatomical_structure Neurology Optic nerve Neurology (clinical) medicine.symptom Cardiology and Cardiovascular Medicine Glycolysis Neuroscience Anaerobic exercise Feature Article Commentary |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism. 31:996-1002 |
| ISSN: | 1559-7016 0271-678X |
| Popis: | The mammalian central nervous system (CNS) is generally believed to be completely dependent on the presence of oxygen (O2) to maintain energy levels necessary for excitability. However, previous studies on CNS white matter (WM) have shown that a large subset of CNS-myelinated axons of mice aged 4 to 6 weeks remains excitable in the absence of O2. We investigated whether this surprising WM tolerance to anoxia varied with age. Acutely isolated mouse optic nerve (MON), a purely myelinated WM tract, was studied electrophysiologically. Excitability in the MONs from 1-month-, 4-month-, and 8-month-old mice was assessed quantitatively as the area under the supramaximal compound action potential (CAP). Anoxia-resistant WM function declined with age. After 60 minutes of anoxia, ∼23% of the CAP remained in 1-month-old mice, 8% in 4-month-old mice, and ∼0 in the 8-month-old group. Our results indicated that although some CNS axons function anaerobically in young adult animals, they lose this ability in later adulthood. This finding may help explain the clinical impression that favorable outcome after stroke and other brain injuries declines with age. |
| Databáze: | OpenAIRE |
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