Hyperbaric oxygen therapy and ischemia and reperfusion: a valuable association to attenuate ischemic lesion and hepatic reperfusion
| Autor: | Orlando de Castro e Silva, Maria Aparecida Neves Cardoso Picinato, Omar Féres, Maria Cecília Jordani, Paulo Roberto Teixeira Michelone, Daniele Moraes Losada, Clarice Fleury Fina, Maria Eliza Jordani de Souza |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Surgical stress RD1-811 Ischemia lcsh:Surgery Mitochondrial swelling Statistics Nonparametric chemistry.chemical_compound Hyperbaric oxygen Malondialdehyde medicine Ischemic lesion Animals Aspartate Aminotransferases Rats Wistar Hyperbaric Oxygenation business.industry HEPATOPATIAS Alanine Transaminase lcsh:RD1-811 medicine.disease Hepatic ischemia Rats Disease Models Animal chemistry Liver Anesthesia Reperfusion Injury Anesthetic Reperfusion Surgery business Mitochondrial Swelling medicine.drug |
| Zdroj: | Acta Cirurgica Brasileira, Vol 28, Iss 2, Pp 126-130 (2013) Acta Cirurgica Brasileira, Volume: 28, Issue: 2, Pages: 126-130, Published: FEB 2013 Acta Cirúrgica Brasileira v.28 n.2 2013 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1678-2674 |
| Popis: | PURPOSE: To investigate the consequences of the association between hyperbaric oxygen therapy and hepatic ischemia / reperfusion. METHODS: Wistar rats were divided into three groups: SHAM, rats submitted to surgical stress and anesthetic but not hepatic ischemia or reperfusion, I / R, rats submitted to total hepatic pedicle ischemia for 30 min, followed by 5 min of reperfusion; HBO120, rats submitted to 120 min of hyperbaric oxygen therapy at two absolute atmospheres and immediately after submitted to the experimental protocol of ischemia and reperfusion. The preservation of the hepatic function was evaluated by determining mitochondrial swelling and malondialdehyde tissue level, as well as alanine aminotransferase and aspartate aminotranferase serum levels. The results were analyzed using the Mann-Whitney test and differences were considered significant for p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|