Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy?
| Autor: | Rogério Aoki Fuziy, Marcelo Moura Linhares, Valéria P. Lanzoni, Ana Karina Soares Alves, Carlos Toshinori Maeda, Gaspar de Jesus Lopes, Rita Maria Aparecida Monteiro Moura Franco |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Time Factors Proliferative index RD1-811 medicine.medical_treatment Phosphatase Cell- and Tissue-Based Therapy Mesenchymal Stem Cell Transplantation Andrology 03 medical and health sciences 0302 clinical medicine medicine Animals Hepatectomy Rats Wistar Saline Cell Proliferation business.industry Mesenchymal stem cell Albumin Liver regeneration Liver Regeneration Rats 030220 oncology & carcinogenesis Injections Intravenous Models Animal 030211 gastroenterology & hepatology Surgery Liver function business |
| Zdroj: | Acta Cirúrgica Brasileira v.32 n.7 2017 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Volume: 32, Issue: 7, Pages: 515-522, Published: JUL 2017 Acta Cirurgica Brasileira, Vol 32, Iss 7, Pp 515-522 (2017) |
| Popis: | Purpose: To evaluate the effects of mesenchymal stem cells on liver regeneration in rats following a 70% hepatectomy. Methods: Forty rats were subjected to 70% hepatectomy and then ~106 mesenchymal stem cells (test group), or saline solution (control group), were infused into their livers via the portal vein. Each treatment group was divided into early and late subgroups (euthanized 3 d and 5 d following the operation, respectively). Group comparisons of Albumin, aminotransaminases (AST, ALT), and Alcaline Phosphatase (AP) levels, proliferative index (ki-67+ straining), and mitotic cell counts were conducted. Results: No significant differences in liver regeneration rate, number of mitoses, proliferative index, or serum levels of albumin, AST, or AP were observed. ALT levels were higher in the test group than in the control group (p |
| Databáze: | OpenAIRE |
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