Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation

Autor: María Dolores García-Cosío, Francisco González-Vilchez, Raquel López-Vilella, Eduardo Barge-Caballero, Manuel Gómez Bueno, Manuel Martínez-Selles, Jose María Arizón, Diego Rangel Sousa, José González-Costello, Sonia Mirabet, Félix Pérez-Villa, Beatriz Díaz Molina, Gregorio Rábago, Ana Portolés Ocampo, Luis de la Fuente Galán, Iris Garrido, Juan F. Delgado
Rok vydání: 2020
Předmět:
lcsh:Diseases of the circulatory (Cardiovascular) system
Pediatrics
medicine.medical_specialty
Advanced heart failure
medicine.medical_treatment
Enfermedad cardiovascular
Distribución por sexo
Dones
Disease
030204 cardiovascular system & hematology
Heart transplantation
Cardiovascular Medicine
Affect (psychology)
heart transplantation
03 medical and health sciences
advanced heart failure
female
gender
heart transplantation
outcome
ventricular assist device
women
0302 clinical medicine
Trasplantament cardíac
medicine
gender
Factors sexuals en les malalties
Women
030212 general & internal medicine
Prospective cohort study
ventricular assist device
Outcome
Original Research
business.industry
Gender
medicine.disease
advanced heart failure
Trasplante de órganos
Transplantation
female
lcsh:RC666-701
Heart failure
Ventricular assist device
outcome
Sex factors in disease
Female
Transplant patient
women
Cardiology and Cardiovascular Medicine
business
Insuficiencia cardiaca
Zdroj: Frontiers in Cardiovascular Medicine
Dipòsit Digital de la UB
Universidad de Barcelona
Frontiers In Cardiovascular Medicine
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
ISSN: 2297-055X
Popis: Altres ajuts: Centro de Investigación en Red de Enfermedades Cardiovasculares (CIBERCV); Instituto de Salud Carlos III (ISCIII); Ministerio de Economía y Competitividad (MINECO). Biological differences between males and females change the course of different diseases and affect therapeutic measures' responses. Heart failure is not an exception to these differences. Women account for a minority of patients on the waiting list for heart transplantation or other advanced heart failure therapies. The reason for this under-representation is unknown. Men have a worse cardiovascular risk profile and suffer more often from ischemic heart disease. Conversely, transplanted women are younger and more frequently have non-ischemic cardiac disorders. Women's poorer survival on the waiting list for heart transplantation has been previously described, but this trend has been corrected in recent years. The use of ventricular assist devices in women is progressively increasing, with comparable results than in men. The indication rate for a heart transplant in women (number of women on the waiting list for millions of habitants) has remained unchanged over the past 25 years. Long-term results of heart transplants are equal for both men and women. We have analyzed the data of a national registry of heart transplant patients to look for possible future directions for a more in-depth study of sex differences in this area. We have analyzed 1-year outcomes of heart transplant recipients. We found similar results in men and women and no sex-related interactions with any of the factors related to survival or differences in death causes between men and women. We should keep trying to approach sex differences in prospective studies to confirm if they deserve a different approach, which is not supported by current evidence.
Databáze: OpenAIRE
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