Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma

Autor: Marie-Magdeleine Ruchoux, Jacqueline Mikol, Isabelle Salmon, Dominique Figarella-Branger, David W. Ellison, Emmanuel Rousseau, Francesco Scaravilli, Catherine Lacroix, Thomas Palm, Catherine Godfraind, Miikka Vikkula, Françoise Chapon
Přispěvatelé: UCL - MD/MNOP - Département de morphologie normale et pathologique, UCL - MD/BICL - Département de biochimie et de biologie cellulaire, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Centre de génétique médicale UCL, UCL - (SLuc) Centre de malformations vasculaires congénitales
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Ependymoma
Chromosomes
Human
Pair 11 -- genetics
Microsatellite Repeats -- genetics
Male
Pathology
Cancer Research
Tissue Fixation
Trisomy
medicine.disease_cause
Chromosomes
Human
Pair 19 -- genetics
Child
Glial fibrillary acidic protein
biology
Brain Neoplasms
Nucleic Acid Hybridization
Sciences bio-médicales et agricoles
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Oncology
Child
Preschool
Molecular Medicine
Female
Chromosome Deletion
Ependymoma -- pathology
Chromosomes
Human
Pair 9
Adult
medicine.medical_specialty
Adolescent
Chromosome 9
Brain Neoplasms -- genetics
Polymorphism
Single Nucleotide
lcsh:RC254-282
Brain Neoplasms -- pathology
Chromosome 19
medicine
Humans
Tissue Array Analysis -- methods
Ependymoma -- genetics
Aged
Genome
Human
Research
Chromosomes
Human
Pair 11
Infant
Tissue Fixation -- methods
medicine.disease
Nucleic Acid Hybridization -- methods
Tissue Array Analysis
biology.protein
Human genome
Carcinogenesis
Chromosomes
Human
Pair 9 -- genetics
Chromosomes
Human
Pair 19
Clear cell
Microsatellite Repeats
Zdroj: Molecular Cancer, Vol 6, Iss 1, p 47 (2007)
Molecular Cancer, Vol. 6, p. 47 [1-10] (2007)
Molecular Cancer
Molecular cancer, 6
ISSN: 1476-4598
Popis: Ependymal tumors constitute a clinicopathologically heterogeneous group of brain tumors. They vary in regard to their age at first symptom, localization, morphology and prognosis. Genetic data also suggests heterogeneity. We define a newly recognized subset of ependymal tumors, the trisomy 19 ependymoma. Histologically, they are compact lesions characterized by a rich branched capillary network amongst which tumoral cells are regularly distributed. When containing clear cells they are called clear cell ependymoma. Most trisomy 19 ependymomas are supratentorial WHO grade III tumors of the young. Genetically, they are associated with trisomy 19, and frequently with a deletion of 13q21.31-31.2, three copies of 11q13.3-13.4, and/or deletions on chromosome 9. These altered chromosomal regions are indicative of genes and pathways involved in trisomy 19 ependymoma tumorigenesis. Recognition of this genetico-histological entity allows better understanding and dissection of ependymal tumors.
Journal Article
Research Support, Non-U.S. Gov't
info:eu-repo/semantics/published
Databáze: OpenAIRE
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