Peak-time determination of post-meal glucose excursions in insulin-treated diabetic patients
| Autor: | Etienne Larger, C. Dorange-Breillard, A. Sola-Gazagnes, S. Daenen, F. Defer, J. M’Bemba, G. Slama, F. Elgrably |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine Retrospective analysis Diabetes Mellitus Humans Insulin Aged Retrospective Studies Blood glucose monitoring Meal medicine.diagnostic_test business.industry Blood Glucose Self-Monitoring digestive oral and skin physiology Reproducibility of Results General Medicine Middle Aged medicine.disease Time optimal Postprandial Period Rate of increase Postprandial business |
| Zdroj: | Diabetesmetabolism. 36(2) |
| ISSN: | 1878-1780 |
| Popis: | Objective This study aimed to determine the optimal time to measure peak blood glucose values to find the best approach for self-monitoring blood glucose after a meal. Design and methods For this retrospective analysis, 69 ambulatory continuous glucose-monitoring system (CGMS) profiles were obtained from 75 consecutive insulin-treated patients with diabetes. The parameters measured were the peak post-meal blood glucose values, peak time, and rates of increase and decrease to and from the zenith of the resulting curves. Results The mean peak time after breakfast was 72 ± 23 min, which was reached in less than 90 min in 80% of the patients. The apparent glucose rate of increase from pre-meal to the maximum postprandial value was 1.23 ± 0.76 mg/dL/min, while the glucose rate of decrease was 0.82 ± 0.70 mg/dL/min. Peak time correlated with the amplitude of postprandial excursions, but not with the peak glucose value. Also, peak times were similar after breakfast, lunch and dinner, and in type 1 and type 2 diabetic patients. Conclusion To best assess peak postprandial glucose levels, the optimal time for blood glucose monitoring is about 1 h and 15 min after the start of the meal, albeit with wide interpatient variability. Nevertheless, 80% of post-meal blood glucose peaks were observed at less than 90 min after the start of the meal. |
| Databáze: | OpenAIRE |
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