Interaction between Vitamin D-Related Genetic Risk Score and Carbohydrate Intake on Body Fat Composition: A Study in Southeast Asian Minangkabau Women

Autor: Karani Santhanakrishnan Vimaleswaran, Buthaina E. Alathari, Sri Rahma Sari, Finny Fitry Yani, Utami Ariyasra, Nabila Tasrif, Ikhwan R. Sudji, Nur Indrawaty Lipoeto, Julie A. Lovegrove, Arif Sabta Aji
Rok vydání: 2021
Předmět:
Adult
0301 basic medicine
Vitamin
medicine.medical_specialty
carbohydrate intake
lcsh:TX341-641
030209 endocrinology & metabolism
Single-nucleotide polymorphism
Southeast asian
genetic risk score
Polymorphism
Single Nucleotide
Body fat percentage
Article
Body Mass Index
Eating
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Asian People
Risk Factors
Internal medicine
Dietary Carbohydrates
medicine
Vitamin D and neurology
Humans
Vitamin D
Alleles
Carbohydrate intake
Nutrition and Dietetics
business.industry
fungi
Middle Aged
Carbohydrate
metabolic disease
Vitamin D Deficiency
body fat percentage
030104 developmental biology
Endocrinology
Adipose Tissue
chemistry
Indonesia
Body Composition
Linear Models
Female
Minangkabau women
business
lcsh:Nutrition. Foods and food supply
Body mass index
Food Science
Zdroj: Nutrients
Volume 13
Issue 2
Nutrients, Vol 13, Iss 326, p 326 (2021)
ISSN: 2072-6643
DOI: 10.3390/nu13020326
Popis: Metabolic diseases have been shown to be associated with low vitamin D status
however, the findings have been inconsistent. Hence, the objective of our study was to investigate the relationship between vitamin D status and metabolic disease-related traits in healthy Southeast Asian women and examine whether this relationship was modified by dietary factors using a nutrigenetic study. The study included 110 Minangkabau women (age: 25&ndash
60 years) from Padang, Indonesia. Genetic risk scores (GRS) were constructed based on five vitamin D-related single nucleotide polymorphisms (SNPs) (vitamin D-GRS) and ten metabolic disease-associated SNPs (metabolic-GRS). The metabolic-GRS was significantly associated with lower 25-hydroxyvitamin D (25(OH)D) concentrations (p = 0.009) and higher body mass index (BMI) (p = 0.016). Even though the vitamin D-GRS had no effect on metabolic traits (p >
0.12), an interaction was observed between the vitamin D-GRS and carbohydrate intake (g) on body fat percentage (BFP) (pinteraction = 0.049), where those individuals who consumed a high carbohydrate diet (mean ±
SD: 319 g/d ±
46) and carried >
2 vitamin D-lowering risk alleles had significantly higher BFP (p = 0.016). In summary, we have replicated the association of metabolic-GRS with higher BMI and lower 25(OH)D concentrations and identified a novel interaction between vitamin D-GRS and carbohydrate intake on body fat composition.
Databáze: OpenAIRE
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