Possible involvement of organic anion and cation transporters in renal excretion of xanthine derivatives, 3-methylxanthine and enprofylline
| Autor: | Masao Kimura, Shunsuke Kurono, Hiroko Saito, Hideo Yoshizumi, Masayuki Nadai, Miki Kato, Takaaki Hasegawa, Fumie Abe |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Organic cation transport Time Factors Organic Cation Transport Proteins Organic anion transporter 1 Metabolic Clearance Rate Organic Anion Transporters Pharmacology Kidney urologic and male genital diseases General Biochemistry Genetics and Molecular Biology Substrate Specificity chemistry.chemical_compound medicine Animals Rats Wistar General Pharmacology Toxicology and Pharmaceutics biology Probenecid Tetraethylammonium General Medicine Xanthine Rats Kidney Tubules Biochemistry chemistry Xanthines Renal physiology biology.protein Uric acid Enprofylline p-Aminohippuric Acid Cimetidine medicine.drug Organic anion |
| Zdroj: | Life Sciences. 81:1175-1182 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2007.07.032 |
| Popis: | Whether organic anion and cation transporters are involved in the renal excretion of xanthine derivatives, 3-methylxanthie and enprofylline, remains unclear. In this study, we have investigated the effects of typically predominant substrates for organic anion and cation transporters on the tubular secretion of 3-methylxanthine and enprofylline in rats. In the renal clearance experiments using typical substrates for organic anion transporters, probenecid and p-aminohippurate, probenecid (20 mg/kg), but not p-aminohippurate (100 mg/kg), significantly decreased the renal clearance and clearance ratio of 3-methylxanthine and enprofylline. The typical substrates for organic cation transport systems, tetraethylammonium (30.6 mg/kg) and cimetidine (50 or 100 mg/kg), significantly decreased the renal clearance and clearance ratio of 3-methylxanthine and enprofylline. These results suggest that the renal secretory transport of 3-methylxanthine and enprofylline are mediated by probenecid-, cimetidine- and tetraethylammonium-sensitive transport systems. Uric acid, an organic anion, significantly inhibited the renal secretion of 3-methylxanthine, but not enprofylline, suggesting that the renal tubular transport of 3-methylxanthine is also mediated via uric acid-sensitive transport system. These findings suggest the possibility that both organic anion and cation transporters are, at least, involved in the renal tubular transport of 3-methylxanthine and enprofylline in rats. |
| Databáze: | OpenAIRE |
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