Leptin treatment reduces body fat but does not affect lean body mass or the myostatin-follistatin-activin axis in lean hypoleptinemic women
| Autor: | Faidon Magkos, Maria Vamvini, Mary Brinkoetter, Christos S. Mantzoros |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Leptin Follistatin medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Down-Regulation Adipokine Adipose tissue Myostatin Placebos Young Adult Double-Blind Method Metabolic Diseases Thinness Physiology (medical) Internal medicine Humans Medicine Leptin Deficiency biology business.industry Body Weight Articles Activins Endocrinology Adipose Tissue Body Composition Lean body mass biology.protein Female Animal studies business Signal Transduction |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 301:E99-E104 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.00146.2011 |
| Popis: | Animal studies in vivo indicate that leptin treatment in extremely leptin-sensitive ob/ ob mice reduces body weight exclusively by reducing fat mass and that it increases muscle mass by downregulating myostatin expression. Data from human trials are limited. Therefore, we aimed at characterizing the effects of leptin administration on fat mass, lean body mass, and circulating regulators of muscle growth in hypoleptinemic and presumably leptin-sensitive human subjects. In an open-label, single-arm trial, seven lean, strenuously exercising, amenorrheic women with low leptin concentrations (≤5 ng/ml) were given recombinant methionyl human leptin (metreleptin; 0.08 mg·kg−1·day−1) for 10 wk. In a separate randomized, double-blind, placebo-controlled trial, seven women were given metreleptin (initial dose: 0.08 mg·kg−1·day−1 for 3 mo, increased thereafter to 0.12 mg·kg−1·day−1 if menstruation did not occur), and six were given placebo for 9 mo. Metreleptin significantly reduced total body fat by an average of 18.6% after 10 wk ( P < 0.001) in the single-arm trial and by 19.5% after 9 mo (placebo subtracted; P for interaction = 0.025, P for metreleptin = 0.004) in the placebo-controlled trial. There were no significant changes in lean body mass ( P ≥ 0.33) or in serum concentrations of myostatin ( P ≥ 0.35), follistatin ( P ≥ 0.30), and activin A ( P ≥ 0.20) whether in the 10-wk trial or the 9-mo trial. We conclude that metreleptin administration in lean hypoleptinemic women reduces fat mass exclusively and does not affect lean body mass or the myostatin-follistatin-activin axis. |
| Databáze: | OpenAIRE |
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