Long non‑coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)

Autor: Xu Ning, Guping Mao, Miao Liu, Hongbin Wu, Guoxuan Peng, Jin Deng, Hong Sun, Hua Yang
Rok vydání: 2020
Předmět:
Zdroj: Biomedical Reports
ISSN: 2049-9442
2049-9434
DOI: 10.3892/br.2020.1305
Popis: Osteogenic differentiation originating from mesenchymal stem cells (MSCs) requires tight co-ordination of transcriptional factors, signaling pathways and biomechanical cues. Dysregulation of such reciprocal networks may influence the proliferation and apoptosis of MSCs and osteoblasts, thereby impairing bone metabolism and homeostasis. An increasing number of studies have shown that long non-coding (lnc)RNAs are involved in osteogenic differentiation and thus serve an important role in the initiation, development, and progression of bone diseases such as tumors, osteoarthritis and osteoporosis. It has been reported that the lncRNA, maternally expressed gene 3 (MEG3), regulates osteogenic differentiation of multiple MSCs and also acts as a critical mediator in the development of bone formation and associated diseases. In the present review, the proposed mechanisms underlying the roles of MEG3 in osteogenic differentiation and its potential effects on bone diseases are discussed. These discussions may help elucidate the roles of MEG3 in osteogenic differentiation and highlight potential biomarkers and therapeutic targets for the treatment of bone diseases.
Databáze: OpenAIRE
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