The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial
| Autor: | Julie Larsen, Samantha Skaufel, Bhagwat Prasad, Kari Thompson, Hans C. Haverkamp, Carolina Pavlenco, Lindsey Miller, Vijaya Saradhi Mettu, Abdul Basit |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Methylsulfonylmethane obesity Physiology Blood lipids Overweight Placebo Article chemistry.chemical_compound High-density lipoprotein Diabetes mellitus medicine overweight Humans TX341-641 Dimethyl Sulfoxide Sulfones Exercise Inflammation Nutrition and Dietetics business.industry Cholesterol Nutrition. Foods and food supply Cholesterol HDL medicine.disease Obesity Fibrosis Diet C-Reactive Protein chemistry cardiometabolic Female medicine.symptom business methylsulfonylmethane Oxidation-Reduction Biomarkers Food Science |
| Zdroj: | Nutrients Volume 13 Issue 10 Pages: 3620 Nutrients, Vol 13, Iss 3620, p 3620 (2021) |
| ISSN: | 2072-6643 |
| Popis: | Interventions to decrease inflammation and improve metabolic function hold promise for the prevention of obesity-related diseases. Methylsulfonylmethane (MSM) is a naturally occurring compound that demonstrates antioxidant and anti-inflammatory effects. Improvements in measures of metabolic health have been observed in mouse models of obesity and diabetes following MSM treatment. However, the effects of MSM on obesity-related diseases in humans have not been investigated. Therefore, the purpose of this investigation was to determine whether MSM supplementation improves cardiometabolic health, and markers of inflammation and oxidative status. A randomized, double-blind, placebo-controlled design was utilized with a total of 22 overweight or obese adults completing the study. Participants received either a placebo (white rice flour) or 3 g MSM daily for 16 weeks. Measurements occurred at baseline and after 4, 8, and 16 weeks. Outcome measures included fasting glucose, insulin, blood lipids, blood pressure, body composition, metabolic rate, and markers of inflammation and oxidative status. The primary finding of this work shows that high-density lipoprotein cholesterol was elevated at 8 and 16 weeks of daily MSM consumption compared to baseline, (p = 0.008, p = 0.013). Our findings indicate that MSM supplementation may improve the cholesterol profile by resulting in higher levels of high-density lipoprotein cholesterol. |
| Databáze: | OpenAIRE |
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