Longitudinal Macular Retinal and Choroidal Microvasculature Changes in High Myopia
| Autor: | Jian Xiong, Xinbo Gao, Fengbin Lin, Weijing Cheng, Xiulan Zhang, Yunhe Song, Zhenni Zhao, Meiling Chen, Peiyuan Wang, Mingkui Tan, Zhen Qiu, Bin Yang, Chunman Yang, Yifeng Yu, Fanyin Wang, Kun Hu, Xiaohong Liang, Fei Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
genetic structures Visual Acuity Eye Ophthalmology & Optometry Medical and Health Sciences chemistry.chemical_compound Myopia Medicine Longitudinal Studies Prospective Studies Fluorescein Angiography high myopia Tomography Clinical and Epidemiologic Research Degenerative longitudinal study High myopia Biological Sciences Middle Aged Healthy Volunteers choriocapillaris Myopia Degenerative Female Tomography Optical Coherence Adult medicine.medical_specialty Capillary plexus retinal capillary density Clinical Research Ophthalmology Healthy control Humans Eye Disease and Disorders of Vision Intraocular Pressure GSHM Study Group business.industry Choroid Retinal Vessels Retinal Optical coherence tomography angiography eye diseases Capillaries Microvascular Network Capillary density chemistry Optical Coherence sense organs business Follow-Up Studies |
| Zdroj: | Investigative Ophthalmology & Visual Science Investigative ophthalmology & visual science, vol 62, iss 15 |
| ISSN: | 1552-5783 0146-0404 |
| Popis: | Purpose The purpose of this study was to determine the longitudinal changes in macular retinal and choroidal microvasculature in normal healthy and highly myopic eyes. Methods Seventy-one eyes, including 32 eyes with high myopia and 39 healthy control eyes, followed for at least 12 months and examined using optical coherence tomography angiography imaging in at least 3 visits, were included in this study. Fovea-centered 6 × 6 mm scans were performed to measure capillary density (CD) of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC). The rates of CD changes in both groups were estimated using a linear mixed model. Results Over a mean 14-month follow-up period, highly myopic eyes exhibited a faster rate of whole image CD (wiCD) loss (−1.44%/year vs. −0.11%/year, P = 0.001) and CD loss in the outer ring of the DCP (−1.67%/year vs. –0.14%/year, P < 0.001) than healthy eyes. In multivariate regression analysis, baseline axial length (AL) was negatively correlated with the rate of wiCD loss (estimate = −0.27, 95% confidence interval [CI] = −0.48 to −0.06, P = 0.012) and CD loss in the outer ring (estimate = −0.33, 95% CI = −0.56 to −0.11, P = 0.005), of the DCP. The CD reduction rates in the SCP and CC were comparable in both groups (all P values > 0.05). Conclusions The rate of CD loss in the DCP is significantly faster in highly myopic eyes than in healthy eyes and is related to baseline AL. The CD in the outer ring reduces faster in eyes with longer baseline AL. |
| Databáze: | OpenAIRE |
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