Taxifolin attenuates ischemia-reperfusion induced oxidative ovarian damage in rats
| Autor: | Umit Nayki, Nesrin Yilmaz, Kemal Dinc, Gulce Naz Yazici, Mine Gulaboglu, Nihal Menzi Çetin, Tunay Kiremitli, Sevil Kiremitli, Renad Mammadov, Can Turkler |
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| Rok vydání: | 2021 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Ischemia Plant Science Oxidative phosphorylation medicine.disease_cause Sham group chemistry.chemical_compound Internal medicine medicine Taxifolin cardiovascular diseases Normal range General Veterinary business.industry Ovarian torsion Obstetrics and Gynecology Malondialdehyde medicine.disease female genital diseases and pregnancy complications Endocrinology Reproductive Medicine chemistry antioxidants ischemia-reperfusion ovarian damage rat taxifolin oxidative stress ovarian torsion Medicine Animal Science and Zoology business Oxidative stress |
| Zdroj: | Asian Pacific Journal of Reproduction, Vol 10, Iss 4, Pp 168-175 (2021) |
| ISSN: | 2305-0500 |
| Popis: | Objective: To investigate preventive effects of taxifolin on ischemia-reperfusion induced oxidative ovarian damage in rats. Methods: A total of 18 female Wistar albino rats were randomly and equally divided into three groups: the sham group, the ovarian ischemia reperfusion group, and the 50 mg/kg taxifolin+ovarian ischemia reperfusion group. The ovarian ischemia reperfusion and taxifolin+ovarian ischemia reperfusion groups were exposed to ischemia for 2 h and then followed by two-hour reperfusion protocol. Biochemical and histopathologic examinations were performed on the extracted ovaries. Results: Levels of malondialdehyde and cyclooxygenase-2 were increased, while reduced-glutathione and cyclooxygenase-1 were decreased in the ovarian ischemia reperfusion group. However, these values were reversed in the taxifolin+ovarian ischemia reperfusion group. Similarly, the number of primordial and developing follicules decreased in the ovarian ischemia reperfusion group, while they were within normal range in the taxifolin+ovarian ischemia reperfusion group. Conclusions: Ischemia followed by reperfusion leads to oxidative stress-related ovarian injury, and taxifolin may be useful for protecting ovarian tissue from such injury. |
| Databáze: | OpenAIRE |
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