Hemodynamic Effects of Amrinone in Children After Fontan Surgery
| Autor: | Chandra Ramamoorthy, J. G. Stevenson, J. W. French, G. K. Sorensen, Anne M. Lynn |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Heart Defects
Congenital Pulmonary Circulation medicine.medical_specialty Cardiac output Cardiotonic Agents Vasodilator Agents Cardiac index Hemodynamics Fontan Procedure Amrinone Internal medicine medicine Humans Prospective Studies Cardiac Output Child Postoperative Care business.industry Central venous pressure Infant Stroke volume Surgery Anesthesiology and Pain Medicine medicine.anatomical_structure Blood pressure Child Preschool Anesthesia cardiovascular system Cardiology Vascular resistance Vascular Resistance business medicine.drug |
| Zdroj: | Anesthesia & Analgesia. 82:241-246 |
| ISSN: | 0003-2999 |
| DOI: | 10.1097/00000539-199602000-00004 |
| Popis: | After Fontan repair in children, we performed a prospective, open-label study to evaluate the effect of amrinone on pulmonary vascular resistance (PVRI). Eight patients who underwent the Fontan repair had baseline arterial pressure, left atrial pressure, central venous pressure, and cardiac output measured postoperatively. Hemodynamic measurements were repeated after amrinone 4.5 mg/kg. The PVRI tended to decrease, but the change was not statistically significant. Although the systemic vascular resistance decreased to 802 +/- 222 from 941 +/- 191 dynes.s.cm-5.m-2 (P < 0.05), mean arterial blood pressure was unchanged. Cardiac index (3.8 +/- 1.2 to 4.7 +/- 1.6 L.min-1.m-2) and stroke volume index (23.6 +/- 6.7 to 30.5 +/- 8.1 mL.beat-1.m-2) increased, and heart rate decreased (160 +/- 21 to 151 +/- 24 bpm) (P < 0.05). Colloid transfusion during amrinone bolus administration was 13.9 mL/kg. The mean serum amrinone concentration was 4.2 micrograms/mL at the end of bolus and clearance was 2.24 mL.kg-1.min-1. Arrhythmias and thrombocytopenia were not noted. We conclude that amrinone administration is effective in increasing cardiac output in children who have undergone a Fontan repair. |
| Databáze: | OpenAIRE |
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