Pathogenetic Role of the Stress-induced Release of Glucocorticoid Hormones in the Development of Post-traumatic Stress Disorder: An Experimental Study

Autor:	Elena Rybnikova, M. Y. Zenko, K. A. Baranova
Rok vydání:	2018
Předmět:	Male medicine.medical_specialty behavioral disciplines and activities General Biochemistry Genetics and Molecular Biology Stress Disorders Post-Traumatic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Corticosterone Internal medicine mental disorders medicine Animals Enzyme Inhibitors Rats Wistar Glucocorticoid hormones Ischemic Preconditioning Glucocorticoids Glucocorticoid synthesis General Immunology and Microbiology Metyrapone Experimental model business.industry Stress induced Traumatic stress General Medicine Rats 030227 psychiatry Posttraumatic stress Endocrinology chemistry General Agricultural and Biological Sciences business 030217 neurology & neurosurgery medicine.drug
Zdroj:	Doklady Biological Sciences. 479:51-53
ISSN:	1608-3105 0012-4966
DOI:	10.1134/s0012496618020059
Popis:	In the rat experimental model of posttraumatic stress disorder (PTSD), the level of blood corticosterone was at least eight-fold increased (an overrelease). The use of hypobaric hypoxic preconditioning or short-term inhibition of glucocorticoid synthesis by metyrapone injection prevented development of the experimental PTSD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae70bd281caa43443c652a3fac40718 https://doi.org/10.1134/s0012496618020059 Zobrazit plný text záznamu Full text from SpringerLink