Relationship between the Crystal Structure and Tuberculostatic Activity of Some 2-Amidinothiosemicarbazone Derivatives of Pyridine
| Autor: | Katarzyna Gobis, Małgorzata Szczesio, Andrzej Olczak, Tomasz Pawlak, Ewa Augustynowicz-Kopeć, Malwina Krause, Marek L. Główka |
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| Rok vydání: | 2021 |
| Předmět: |
pyridine
Technology Microscopy QC120-168.85 QH201-278.5 crystal state X-ray 15N NMR study Engineering (General). Civil engineering (General) Article TK1-9971 Descriptive and experimental mechanics SAR-analysis General Materials Science 2-amidinothiosemicarbazones Electrical engineering. Electronics. Nuclear engineering tuberculostatic activity TA1-2040 |
| Zdroj: | Materials Materials, Vol 15, Iss 349, p 349 (2022) Materials; Volume 15; Issue 1; Pages: 349 |
| ISSN: | 1996-1944 |
| Popis: | Tuberculosis remains one of the most common diseases affecting developing countries due to difficult living conditions, the rapidly increasing resistance of M. tuberculosis strains and the small number of effective anti-tuberculosis drugs. This study concerns the relationship between molecular structure observed in a solid-state by X-ray diffraction and the 15N NMR of a group of pyridine derivatives, from which promising activity against M. tuberculosis was reported earlier. It was found that the compounds exist in two tautomeric forms: neutral and zwitterionic. The latter form forced the molecules to adopt a stable, unique, flat frame due to conjugation and the intramolecular hydrogen bond system. As the compounds exist in a zwitterionic form in the crystal state generally showing higher activity against tuberculosis, it may indicate that this geometry of molecules is the “active” form. |
| Databáze: | OpenAIRE |
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